{"id":"W2074744858","doi":"10.1111/j.1574-6968.1997.tb10246.x","title":"Site-directed mutagenesis of the cysteine residues in the Pichia stipitis xylose reductase","year":2006,"lang":"en","type":"article","venue":"FEMS Microbiology Letters","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Diabetes Association","keywords":"Pichia stipitis; Biochemistry; Cysteine; Xylose metabolism; Cofactor; Xylose; Reductase; Chemistry; Enzyme; Mutagenesis; Yeast; Biology; Saccharomyces cerevisiae; Mutant; Fermentation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792325,0.0005053472,0.0002675953,0.000168005,0.000141223,0.0002299012,0.0004034736,0.0002245245,0.0006070932],"category_scores_gemma":[0.0002744489,0.0001586999,0.0002674361,0.0002556079,0.0003725429,0.0001127375,0.0002849412,0.0005143564,0.0002478557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003681577,"about_ca_system_score_gemma":0.0002658866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080486,"about_ca_topic_score_gemma":0.001417971,"domain_scores_codex":[0.9998294,0.00005483045,0.00002437694,0.00002496809,0.00004281597,0.00002348416],"domain_scores_gemma":[0.9997572,0.00008420083,0.00006316589,0.00003606364,0.00002523453,0.00003406618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001714968,0.00004133056,0.0002715854,0.00004653382,0.00001355718,0.000187135,0.00003571903,0.0003583392,0.9968979,0.0002973061,0.00003079866,0.001648266],"study_design_scores_gemma":[0.00002750005,0.0002168467,0.002976508,0.000006984765,0.00004352753,0.0003841758,0.00003258576,0.001451646,0.9923422,0.00007057154,0.002438547,0.000008872754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870983,0.0003069178,0.01108042,0.00007638505,0.00003412895,0.00009781432,0.0002860395,0.00007366519,0.0009463159],"genre_scores_gemma":[0.990041,0.000403833,0.007740704,0.00003905518,0.00001073013,0.00004352465,0.0004435054,0.00004258047,0.001235067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080486,"threshold_uncertainty_score":0.002671242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003361637287429203,"score_gpt":0.1951963510053352,"score_spread":0.191834713717906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}