{"id":"W2074750860","doi":"10.1038/nn.3786","title":"Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","year":2014,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1006,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute on Aging","keywords":"CpG site; DNA methylation; Methylation; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395215,0.0003118633,0.0002928265,0.0005230453,0.0002092022,0.0002245664,0.0001784419,0.0002515923,0.002152857],"category_scores_gemma":[0.0001793971,0.0001932771,0.0001521469,0.000276522,0.0002073789,0.0002054593,0.0002433173,0.0003921016,0.0002536468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490793,"about_ca_system_score_gemma":0.0001852461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00201223,"about_ca_topic_score_gemma":0.00323958,"domain_scores_codex":[0.9999342,0.000006443938,0.000004703178,0.00001979712,0.00001591078,0.00001907316],"domain_scores_gemma":[0.9999093,0.0000106099,0.00003294226,0.000008376072,0.00001451817,0.00002424784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00152383,0.00004418516,0.01078454,0.00007901858,0.00005016901,0.0006121065,0.000099426,0.00008463812,0.9777233,0.0001758353,0.0002293957,0.008593577],"study_design_scores_gemma":[0.00004183865,0.0002866718,0.6275984,0.00002138475,0.00009490333,0.004542545,0.000212139,0.0003232924,0.3635518,0.000824251,0.002479924,0.00002292214],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928815,0.002890721,0.00176452,0.0001116136,0.0000299474,0.00001058058,0.0007656695,0.00008789129,0.001457528],"genre_scores_gemma":[0.9957094,0.0005794725,0.0009167223,0.00003917009,0.000008188345,0.00001109224,0.0004388941,0.00001647502,0.002280595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002152857,"threshold_uncertainty_score":0.007202029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172674519452725,"score_gpt":0.2809473099680377,"score_spread":0.2692205647735104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}