{"id":"W2074783650","doi":"10.1371/journal.pgen.1000361","title":"Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans","year":2009,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":510,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University; Hereditary Disease Foundation","keywords":"Biology; Superoxide dismutase; Caenorhabditis elegans; Mutant; Oxidative stress; Paraquat; Reactive oxygen species; Mitochondrion; Phenotype; Genetics; Gene; Cell biology; Wild type; Superoxide; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001015425,0.000491582,0.0002188783,0.0003478712,0.0002266314,0.0002644165,0.0003196613,0.0003345576,0.0008767816],"category_scores_gemma":[0.0001134435,0.0002457073,0.0002635072,0.0001239389,0.0001941843,0.0001994973,0.0002954257,0.0005318229,0.0002900917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003401006,"about_ca_system_score_gemma":0.0003048553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002227112,"about_ca_topic_score_gemma":0.004672408,"domain_scores_codex":[0.999898,0.0000057149,0.00001817146,0.00003312049,0.00002806288,0.00001710969],"domain_scores_gemma":[0.9997461,0.00003416237,0.00007413754,0.00002273301,0.00002185724,0.0001010168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008211844,0.00003641451,0.0003379924,0.00003349208,0.000006342672,0.00008066041,0.00001109737,0.0001287008,0.9985475,0.0000389895,0.00004081641,0.0006558539],"study_design_scores_gemma":[0.0001025758,0.0007146969,0.02711785,0.00005541529,0.00006301006,0.0006225926,0.00008313744,0.003826179,0.9637494,0.0001117591,0.003521344,0.00003210156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968221,0.000537359,0.0008761482,0.00006202112,0.00002966998,0.00002066163,0.0007758997,0.0001112148,0.0007647547],"genre_scores_gemma":[0.9920309,0.0007236957,0.002953168,0.00007239905,0.000008985703,0.00005072037,0.0008035291,0.00004375264,0.003312825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002227112,"threshold_uncertainty_score":0.004428327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008300496026547704,"score_gpt":0.2165706282544922,"score_spread":0.2082701322279445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}