{"id":"W2074801231","doi":"10.1371/journal.pgen.1003284","title":"Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Medical Research Council; Universität des Saarlandes; Institut National Du Cancer; Herlev Hospital; Fondation de France; Ligue Contre le Cancer; Lon V. Smith Foundation; National Institute for Health and Care Research; National Health and Medical Research Council; Georgetown University; Cancer Research UK; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Huntsman Cancer Institute; Cancer Care Ontario; Deutsche Gesetzliche Unfallversicherung; Deutsches Krebsforschungszentrum; European Commission; CHIST-ERA; Agence Nationale de la Recherche; National Cancer Institute; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Biology; Breast cancer; Genetics; Gene–environment interaction; Gene; Bioinformatics; Cancer; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007750872,0.0001907708,0.0001906416,0.00003592278,0.0000939309,0.00002632527,0.0001933052,0.0001112077,0.0004826168],"category_scores_gemma":[0.00002128723,0.0001872431,0.0000643421,0.00004614174,0.0002737784,0.00001458411,0.0001927239,0.000130912,0.00001249049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321183,"about_ca_system_score_gemma":0.00004881994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002174909,"about_ca_topic_score_gemma":0.00009808812,"domain_scores_codex":[0.9987718,0.0001014241,0.0003122399,0.0004127941,0.0001937469,0.0002079875],"domain_scores_gemma":[0.999094,0.00005335405,0.0001884985,0.0005151506,0.00003279521,0.0001162077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000008884255,0.00006423933,0.5794764,0.00001495461,0.00009164013,7.826131e-8,0.0001300605,0.000444421,0.4164181,1.27229e-7,0.0001749728,0.003176092],"study_design_scores_gemma":[0.0001526813,0.0001064509,0.5084893,0.0000160927,0.0001117479,0.000002294973,0.0002024524,0.0003698592,0.4900659,0.00002741596,0.0002904921,0.0001653588],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961829,0.002422375,0.0002604883,0.0001148015,0.00006611924,0.0003651664,0.0005576563,0.000007031929,0.00002348939],"genre_scores_gemma":[0.9954502,0.002973792,0.001137174,0.00002911985,0.0001402937,0.00006604588,0.0001136678,0.00002881355,0.00006087144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07364779,"threshold_uncertainty_score":0.763555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287654330217083,"score_gpt":0.2647286193593911,"score_spread":0.2418520760572203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}