{"id":"W2074801231","doi":"10.1371/journal.pgen.1003284","title":"Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Medical Research Council; Universität des Saarlandes; Institut National Du Cancer; Herlev Hospital; Fondation de France; Ligue Contre le Cancer; Lon V. Smith Foundation; National Institute for Health and Care Research; National Health and Medical Research Council; Georgetown University; Cancer Research UK; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Huntsman Cancer Institute; Cancer Care Ontario; Deutsche Gesetzliche Unfallversicherung; Deutsches Krebsforschungszentrum; European Commission; CHIST-ERA; Agence Nationale de la Recherche; National Cancer Institute; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Biology; Breast cancer; Genetics; Gene–environment interaction; Gene; Bioinformatics; Cancer; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006468256,0.0008161996,0.001104871,0.001469537,0.0004960374,0.00133849,0.0009956871,0.0008423963,0.002963632],"category_scores_gemma":[0.009738859,0.0005502598,0.002231826,0.001698228,0.001318805,0.0005473032,0.001543184,0.000901976,0.0002907862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569545,"about_ca_system_score_gemma":0.000492416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002252593,"about_ca_topic_score_gemma":0.003479895,"domain_scores_codex":[0.9894644,0.005131805,0.0007914627,0.002818669,0.001165719,0.0006278906],"domain_scores_gemma":[0.9754961,0.01466451,0.00573189,0.002355961,0.0008626008,0.0008888978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001649579,0.0000523261,0.9759428,0.0002145345,0.007916425,0.0007471356,0.0002046125,0.0002856337,0.006618573,0.0001932759,0.0001159427,0.006059086],"study_design_scores_gemma":[0.00004101609,0.0003061302,0.995886,0.00002609079,0.001645128,0.0006490617,0.00008514543,0.0002541023,0.0004258248,0.0003388218,0.0003250269,0.00001758352],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836364,0.01049866,0.003205152,0.0004129863,0.00004806806,0.00002299461,0.0005984002,0.00005343043,0.001523905],"genre_scores_gemma":[0.997352,0.0009381847,0.001061583,0.0001004894,0.00004057802,0.0000147368,0.0002927966,0.00001511125,0.0001845819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006468256,"threshold_uncertainty_score":0.03420782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287654330217083,"score_gpt":0.2647286193593911,"score_spread":0.2418520760572203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}