{"id":"W2074822356","doi":"10.1038/nsmb.1894","title":"Structural basis of substrate recognition and specificity in the N-end rule pathway","year":2010,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Peptide; Chemistry; Ubiquitin ligase; Ubiquitin; C-terminus; Stereochemistry; Peptide sequence; N-terminus; Biochemistry; Residue (chemistry); Protein structure; Plasma protein binding; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003712522,0.0003625108,0.0005117347,0.0001718391,0.0006533455,0.0009929347,0.0006098296,0.0008591883,0.001774526],"category_scores_gemma":[0.0006099726,0.0002254552,0.0003492168,0.0001015276,0.0005085645,0.0005822994,0.000347387,0.0009442263,0.00126086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090002,"about_ca_system_score_gemma":0.0003482585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005003392,"about_ca_topic_score_gemma":0.0005426293,"domain_scores_codex":[0.9997855,0.00003877122,0.00001732166,0.0000553492,0.00005244246,0.00005066656],"domain_scores_gemma":[0.9995322,0.0001459671,0.00007591322,0.00006644401,0.00006660567,0.0001128898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012544,0.0001659382,0.001202708,0.00009759314,0.00002536769,0.001392886,0.00007501603,0.004303809,0.9629312,0.01912506,0.0004681492,0.009199742],"study_design_scores_gemma":[0.0001471958,0.0004753436,0.006175029,0.00001784386,0.00003332643,0.002383592,0.00008260509,0.02680238,0.9498056,0.01022213,0.003782099,0.00007285926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796877,0.0008030852,0.01179141,0.0003514368,0.0001028701,0.00003064857,0.00009999518,0.000205915,0.00692691],"genre_scores_gemma":[0.9968504,0.0001598006,0.001915225,0.00008712561,0.00001682809,0.000006375349,0.00009241214,0.00001307297,0.0008587103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001774526,"threshold_uncertainty_score":0.005936384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042484009222362,"score_gpt":0.2621937733492865,"score_spread":0.2517689332570628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}