{"id":"W2074828631","doi":"10.1212/wnl.0b013e3182516244","title":"A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease","year":2012,"lang":"en","type":"article","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":334,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Hotel Dieu Hospital; Université de Montréal","funders":"National Institute on Aging; McDonnell Center for Systems Neuroscience; Parkinsonfonden; National Center for Research Resources; Weill Cornell Medical College; Allergan; National Institutes of Health; Ipsen; H. Lundbeck A/S; ACADIA Pharmaceuticals; Eisai; National Parkinson Foundation; Kyowa Hakko Kirin; National Institute of Diabetes and Digestive and Kidney Diseases; Michael J. Fox Foundation for Parkinson's Research; Johns Hopkins University; National Institute of Mental Health; Northwestern University; National Institute of Neurological Disorders and Stroke; Teva Pharmaceutical Industries; Merz Pharmaceuticals; Biogen; GlaxoSmithKline","keywords":"Parkinson's disease; Double blind; Medicine; Placebo; Randomized controlled trial; Psychiatry; Disease; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005899004,0.0002178674,0.001273231,0.0002606213,0.00002755709,0.000004781827,0.00008641505,0.0001353218,0.00015546],"category_scores_gemma":[0.0002381494,0.0001629564,0.0003432571,0.0001344372,0.0000999605,0.00008396024,0.00004523425,0.000184304,0.0000388243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001394414,"about_ca_system_score_gemma":0.00009203187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008401887,"about_ca_topic_score_gemma":0.00001024355,"domain_scores_codex":[0.9980147,0.0004368615,0.0005239529,0.0003126258,0.000257803,0.0004539913],"domain_scores_gemma":[0.9986922,0.0003390823,0.0002143866,0.0003555796,0.00003573878,0.0003630807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9652144,0.002316836,0.03113182,0.00002895298,0.0002150962,0.000217386,0.0000480486,0.000006180533,0.0000803515,0.0004271097,0.00002899426,0.0002848731],"study_design_scores_gemma":[0.9831718,0.0006645228,0.01314364,0.0000141472,0.0006986787,0.00001654953,0.000001421451,0.0002370987,0.0001814526,0.0002318125,0.001541418,0.00009741047],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906998,0.001024695,0.00002463891,0.0005263893,0.0007102414,0.005080709,0.00001008684,0.0000347111,0.001888776],"genre_scores_gemma":[0.9977833,0.0001896293,0.00003636198,0.0004988842,0.0002298768,0.001123487,0.00001950779,0.00002671929,0.00009225351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01798818,"threshold_uncertainty_score":0.6645168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03261143595088837,"score_gpt":0.3046588818748225,"score_spread":0.2720474459239342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}