{"id":"W2074841269","doi":"10.1111/hae.12411","title":"Current status of haemophilia gene therapy","year":2014,"lang":"en","type":"review","venue":"Haemophilia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Rosetrees Trust; National Institute for Health and Care Research","keywords":"Haemophilia; Genetic enhancement; Medicine; Haemophilia B; Factor IX; Transgene; Haemophilia A; Transduction (biophysics); Gene delivery; Gene transfer; Gene; Immunology; Bioinformatics; Biology; Genetics; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002520951,0.0005220506,0.0009524281,0.0009739056,0.0006395421,0.003106863,0.001207752,0.003400506,0.02426751],"category_scores_gemma":[0.003002096,0.0003055551,0.000446129,0.001143092,0.001048048,0.003404673,0.00093252,0.003411423,0.01266295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001078565,"about_ca_system_score_gemma":0.002079545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005929024,"about_ca_topic_score_gemma":0.0007712194,"domain_scores_codex":[0.9992056,0.0001779943,0.0001144084,0.0001145505,0.0003209402,0.00006654671],"domain_scores_gemma":[0.9974914,0.001039853,0.0002941979,0.00008491957,0.0006654277,0.0004242806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001268099,0.00009258909,0.0002130281,0.003491896,0.00002671086,0.00009498611,0.0000743899,0.0001691827,0.001639874,0.007886963,0.1120452,0.8741383],"study_design_scores_gemma":[0.00001679767,0.00009429802,0.0002469856,0.0009346711,0.00002420245,0.0003161039,0.00004236904,0.0001132593,0.0004261348,0.00242668,0.9953458,0.00001268002],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005982608,0.9640918,0.001669835,0.01428489,0.005032824,0.00002261367,0.0001297666,0.0001309591,0.01403903],"genre_scores_gemma":[0.008088916,0.9540845,0.002975205,0.009343779,0.007724642,0.0001206343,0.0005866247,0.00005525852,0.0170204],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02426751,"threshold_uncertainty_score":0.08118284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06755464702954414,"score_gpt":0.3856219036215462,"score_spread":0.3180672565920021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}