{"id":"W2074849860","doi":"10.1186/1471-2407-11-268","title":"Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells","year":2011,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Advances in Cucurbitaceae Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Manitoba","funders":"Leukemia and Lymphoma Society of Canada; CancerCare Manitoba Foundation; Manitoba Health Research Council; Leukemia and Lymphoma Society","keywords":"XIAP; Cell cycle; Apoptosis; Molecular biology; Signal transduction; MAPK/ERK pathway; Kinase; p38 mitogen-activated protein kinases; Cell cycle checkpoint; Transfection; Cell biology; Phosphorylation; Cancer research; Chemistry; Cell culture; Biology; Programmed cell death; Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006866831,0.0004280254,0.0001430085,0.0002347196,0.0001563178,0.0001300037,0.0001415222,0.0001569641,0.001009849],"category_scores_gemma":[0.00005452846,0.00007445485,0.0002095767,0.0001727548,0.0001787881,0.0001118603,0.00008646739,0.0003810679,0.0002971735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003355484,"about_ca_system_score_gemma":0.0001882147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009211659,"about_ca_topic_score_gemma":0.001189376,"domain_scores_codex":[0.9999368,0.00000917495,0.000004903471,0.0000100273,0.00002043838,0.00001870118],"domain_scores_gemma":[0.9999495,0.000005015008,0.00001739329,0.000004901158,0.000006787241,0.0000163694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467381,0.00004095969,0.0001185867,0.00004979874,0.000003349001,0.00003834426,0.000007139638,0.00004574952,0.9988576,0.00002887159,0.00005955691,0.0006033615],"study_design_scores_gemma":[0.00003822049,0.0004513152,0.004322512,0.000006189481,0.00001209029,0.0002728315,0.00001841114,0.0006146297,0.9925447,0.00001995509,0.001695774,0.000003362647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946923,0.001994951,0.001010079,0.00008699505,0.00002604414,0.00003695907,0.000454364,0.00009643083,0.001601908],"genre_scores_gemma":[0.9957938,0.0009182972,0.0008112946,0.00004073523,0.000009634674,0.00004418104,0.0007804845,0.00001235049,0.001589309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009849,"threshold_uncertainty_score":0.003378272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02564276755798777,"score_gpt":0.2783875841310858,"score_spread":0.252744816573098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}