{"id":"W2074863873","doi":"10.1073/pnas.0913835107","title":"In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8 <sup>+</sup> T cell inflammation","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Diabetes Fonds; Canadian Diabetes Association","keywords":"Inflammation; Biology; NOD mice; Immunology; CD8; T cell; Antigen; Epitope; Bystander effect; Cytotoxic T cell; Immune system; Autoimmunity; Cell biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008413503,0.00006404013,0.00009814485,0.0001244298,0.00003979298,0.00001126184,0.0003255696,0.0001395301,0.00001530391],"category_scores_gemma":[0.0002657198,0.00005275257,0.00004357227,0.0003325163,0.0002501602,0.0000594687,0.00006413885,0.0001216117,9.257486e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006471484,"about_ca_system_score_gemma":0.00004362038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002982651,"about_ca_topic_score_gemma":0.000002615631,"domain_scores_codex":[0.9990805,0.000008217707,0.000281763,0.0001684128,0.0003460371,0.0001150627],"domain_scores_gemma":[0.9995236,0.00001271977,0.0002806733,0.000009081665,0.0001584872,0.00001547396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001337462,0.00007168087,0.006131915,0.00002391157,0.000003986983,2.715996e-9,0.0001785939,0.0001702258,0.9922605,0.0006214245,0.00003525738,0.0004890876],"study_design_scores_gemma":[0.0002913008,0.00005283142,0.03725561,0.00002460912,0.000003923956,4.634248e-7,0.0002457915,0.0007162179,0.9498914,0.01135947,0.00009606215,0.00006234693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958566,0.00003198522,1.819363e-7,0.0005624553,0.00001300142,0.0001118251,0.000007274269,0.000002034687,0.003414595],"genre_scores_gemma":[0.9994438,0.00003212939,0.0003509183,0.00006442689,0.00004166823,0.000005954088,0.000003829697,0.00000324952,0.00005396625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04236918,"threshold_uncertainty_score":0.2151187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014671236367669,"score_gpt":0.2614958195847815,"score_spread":0.2513491072211048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}