{"id":"W2074863873","doi":"10.1073/pnas.0913835107","title":"In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8 <sup>+</sup> T cell inflammation","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Diabetes Fonds; Canadian Diabetes Association","keywords":"Inflammation; Biology; NOD mice; Immunology; CD8; T cell; Antigen; Epitope; Bystander effect; Cytotoxic T cell; Immune system; Autoimmunity; Cell biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963546,0.0002516629,0.0001502974,0.0001349039,0.0001356402,0.0002999104,0.0001465608,0.0003673028,0.001093184],"category_scores_gemma":[0.00009487843,0.0001502335,0.0001192382,0.00006529169,0.0003056711,0.0001735804,0.0002062198,0.000465724,0.0004229667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107369,"about_ca_system_score_gemma":0.00008667891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000886119,"about_ca_topic_score_gemma":0.0001769939,"domain_scores_codex":[0.9998516,0.00002912051,0.00001367308,0.00003465585,0.00004179982,0.00002908269],"domain_scores_gemma":[0.9998989,0.00001814769,0.00002822179,0.00001476379,0.000008315108,0.00003160537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005696043,0.000008809983,0.0001209416,0.00001444123,9.490638e-7,0.00005115335,0.000005376485,0.00001968708,0.9991769,0.00006924706,0.00001922324,0.0004562239],"study_design_scores_gemma":[0.00002721835,0.0002728404,0.00633127,0.00001002664,0.0000136572,0.001045472,0.00003011516,0.0007376167,0.9886292,0.000180084,0.002719055,0.000003421976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905929,0.002069205,0.004135399,0.0002426211,0.00005735834,0.00001529993,0.00008805625,0.0001132082,0.002686033],"genre_scores_gemma":[0.9944394,0.0006792386,0.002673484,0.00009820113,0.00003398718,0.00001902364,0.0001155674,0.00002293407,0.001918158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093184,"threshold_uncertainty_score":0.003657043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014671236367669,"score_gpt":0.2614958195847815,"score_spread":0.2513491072211048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}