{"id":"W2074882853","doi":"10.1016/j.molonc.2009.09.003","title":"Topoisomerase IIα‐dependent induction of a persistent DNA damage response in response to transient etoposide exposure","year":2009,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"Etoposide; Topoisomerase; DNA damage; Trichostatin A; DNA replication; Biology; Chromatin; DNA; Histone deacetylase; DNA repair; Molecular biology; Histone; Teniposide; Cell biology; Cancer research; Chemistry; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008813462,0.0001913208,0.000279515,0.0002172877,0.00003818838,0.000009907095,0.0002094012,0.0002776478,0.00002102459],"category_scores_gemma":[0.00009303268,0.0002052889,0.0002154512,0.0002024648,0.00004207726,0.000003814273,0.00005386226,0.0001491961,0.000004355773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726845,"about_ca_system_score_gemma":0.0002825684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002637021,"about_ca_topic_score_gemma":0.00007654983,"domain_scores_codex":[0.9980795,0.0005886335,0.0003637269,0.0004482809,0.0001929393,0.000326963],"domain_scores_gemma":[0.9991899,0.00002309355,0.00009234857,0.0004596194,0.00009211447,0.0001429391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02003668,0.000335039,0.00001375877,0.000005475882,0.00004998015,0.0001354143,0.0007632719,0.001353525,0.9707854,0.00007490697,0.00005317449,0.006393387],"study_design_scores_gemma":[0.002394142,0.01430245,0.004318791,0.00002153886,0.0000467907,0.00007056542,0.0006053697,0.00002654235,0.9529087,0.00008300276,0.02496503,0.0002570673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925371,0.0004962035,0.001811935,0.004266575,0.0002048878,0.0004471339,0.00001769334,0.000009450698,0.0002090131],"genre_scores_gemma":[0.9962955,0.00004253152,0.0006943058,0.002607232,0.00003980617,0.00004386373,0.00002039507,0.0000207232,0.0002356317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02491186,"threshold_uncertainty_score":0.837144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189520426877066,"score_gpt":0.2815372473441793,"score_spread":0.2696420430754086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}