{"id":"W2074886451","doi":"10.1111/j.1467-7652.2006.00214.x","title":"Therapeutic effectiveness of orally administered transgenic low‐alkaloid tobacco expressing human interleukin‐10 in a mouse model of colitis","year":2006,"lang":"en","type":"article","venue":"Plant Biotechnology Journal","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Robarts Clinical Trials; Lawson Health Research Institute; Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada; Kidney Foundation of Canada; London Health Sciences Centre","keywords":"Ulcerative colitis; Inflammatory bowel disease; Inflammation; Immunology; Tumor necrosis factor alpha; Colitis; Cytokine; Transgene; Biology; Genetically modified mouse; Pharmacology; Disease; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829221,0.000417803,0.0004530408,0.0002720861,0.0001472609,0.0003152932,0.0002657021,0.000574523,0.0008617164],"category_scores_gemma":[0.0001191527,0.0001663227,0.0002541843,0.0001785083,0.0004052323,0.0002396366,0.0001098785,0.001122567,0.0002595363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541731,"about_ca_system_score_gemma":0.0002427278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005422407,"about_ca_topic_score_gemma":0.0007986896,"domain_scores_codex":[0.9998499,0.00003474809,0.00001159352,0.00002837663,0.00004069889,0.00003474925],"domain_scores_gemma":[0.9998399,0.00002997566,0.00004668419,0.00001487104,0.00001081835,0.00005765657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006607939,0.0003311954,0.00008156214,0.00003991192,0.000007292273,0.00004331542,0.0000138145,0.00006294428,0.997517,0.00005929342,0.00003830788,0.001144627],"study_design_scores_gemma":[0.0002543982,0.008530311,0.002242909,0.00001910454,0.00007659363,0.00024136,0.00004879799,0.001369969,0.985164,0.00008435189,0.001957384,0.00001081128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945086,0.001524654,0.001722083,0.0002347291,0.0001142067,0.00006460943,0.0002813012,0.0001705013,0.001379544],"genre_scores_gemma":[0.9927918,0.001606084,0.002179536,0.00009274659,0.00002234762,0.00008360829,0.0003731071,0.00002867891,0.002822114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008617164,"threshold_uncertainty_score":0.002882659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543498337653935,"score_gpt":0.2501849570640378,"score_spread":0.2347499736874985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}