{"id":"W2074933455","doi":"10.1038/nature14121","title":"Biocontainment of genetically modified organisms by synthetic protein design","year":2015,"lang":"en","type":"article","venue":"Nature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":462,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Department of Defense; Life Sciences Research Foundation; National Defense Science and Engineering Graduate; U.S. Department of Energy; Howard Hughes Medical Institute","keywords":"Mutagenesis; Organism; Genetically modified organism; Synthetic biology; Biology; Horizontal gene transfer; Biotechnology; Escherichia coli; Computational biology; Model organism; Genetic code; Gene; Biochemical engineering; Genetics; Mutation; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000535646,0.000587406,0.000390503,0.0002855822,0.0002282846,0.0006260891,0.0005868406,0.0005395434,0.000892275],"category_scores_gemma":[0.0005121912,0.000285273,0.0004723873,0.0002558551,0.0004348437,0.0004171109,0.0006393986,0.0007329597,0.00045092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005621677,"about_ca_system_score_gemma":0.0002424676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002275464,"about_ca_topic_score_gemma":0.0004179605,"domain_scores_codex":[0.9995669,0.00008056876,0.00003474256,0.00008401411,0.0001689237,0.00006482605],"domain_scores_gemma":[0.9997463,0.00004759909,0.00008939438,0.00005358609,0.00003791309,0.00002521643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004793946,0.00005021483,0.0001198038,0.0001104902,0.0000169841,0.0001003691,0.00003460146,0.001473415,0.9855875,0.00264775,0.000222971,0.009587906],"study_design_scores_gemma":[0.000007951799,0.0001026047,0.0001223444,0.000004732481,0.00000755562,0.00009775299,0.000007862028,0.002622079,0.9914346,0.0003036012,0.005283164,0.000005796565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7320981,0.003030163,0.2504563,0.0006602179,0.0004094371,0.0002407389,0.0002892749,0.001519051,0.01129668],"genre_scores_gemma":[0.9024756,0.001827626,0.08860736,0.0002179847,0.00003446145,0.0001571847,0.0003510347,0.0002142505,0.00611454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000892275,"threshold_uncertainty_score":0.004078805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007994336066708648,"score_gpt":0.266636796238196,"score_spread":0.2586424601714874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}