{"id":"W2074941863","doi":"10.1158/1538-7445.am2011-lb-283","title":"Abstract LB-283: JX-594, a targeted multi-mechanistic oncolytic poxvirus, selectively infects tumor vasculature and causes acute tumor vascular disruption and necrosis in advanced cancer patients","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Oncolytic virus; Cancer research; Vascular endothelial growth factor; Medicine; Cancer; Tumor necrosis factor alpha; Pathology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008378253,0.0001656995,0.0001673536,0.00008354024,0.0001244385,0.0001741077,0.0001205309,0.0002284829,0.002191652],"category_scores_gemma":[0.00007300602,0.0000624506,0.0001234701,0.00007375426,0.0001505634,0.0001186935,0.0001185525,0.0004063282,0.0004004568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097935,"about_ca_system_score_gemma":0.0001455261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004736164,"about_ca_topic_score_gemma":0.000260612,"domain_scores_codex":[0.9999598,0.000006010668,0.000002759384,0.00001073786,0.0000102295,0.00001048369],"domain_scores_gemma":[0.9999752,0.000004194826,0.000005133602,0.000003183301,0.000003067771,0.00000915918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001167829,0.0003682882,0.001476129,0.00007111443,0.000009545342,0.0002141141,0.00003174934,0.0001307137,0.9873347,0.0001810765,0.0004508675,0.008563917],"study_design_scores_gemma":[0.0005011788,0.01135362,0.02359786,0.00001799675,0.00007384953,0.003838204,0.00005624491,0.002213159,0.9468083,0.0001062419,0.01142446,0.000008942021],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9958317,0.000690985,0.001276606,0.00007410815,0.0000239967,0.00004563503,0.0002114681,0.00006478324,0.001780803],"genre_scores_gemma":[0.9962687,0.0003033501,0.0006802448,0.00005491062,0.00000789415,0.00002879266,0.0004968701,0.00000908016,0.002150241],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002191652,"threshold_uncertainty_score":0.007331848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691756451402433,"score_gpt":0.3593322598259808,"score_spread":0.3224146953119564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}