{"id":"W2074946476","doi":"10.1016/j.jalz.2013.08.263","title":"P4–430: Antisense oligonucleotide‐mediated inhibition of miR‐33 in cultured neurons, astrocytes and microglia: Effects on ABCA1 expression, APOE lipidation, cellular cholesterol and beta‐amyloid neurotoxicity","year":2013,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"ABCA1; Microglia; Neurodegeneration; Neurotoxicity; Biology; Cell biology; Apolipoprotein E; Cholesterol; Amyloid beta; Pharmacology; Chemistry; Biochemistry; Transporter; Immunology; Medicine; Internal medicine; Inflammation; Gene; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242914,0.0006243337,0.0006811549,0.0002150269,0.0002664713,0.0002729066,0.0002593636,0.0005022278,0.001575082],"category_scores_gemma":[0.0001237664,0.0002627664,0.0004357786,0.0002659964,0.0002953722,0.0002208212,0.0001872922,0.0008851709,0.0006732527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338451,"about_ca_system_score_gemma":0.0005988225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001160846,"about_ca_topic_score_gemma":0.001446814,"domain_scores_codex":[0.9997721,0.00003309019,0.00002874712,0.00005007164,0.00006263021,0.00005335102],"domain_scores_gemma":[0.9999152,0.00001478311,0.00001929514,0.000008666505,0.00001883485,0.00002320764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003247459,0.0000893271,0.00002989907,0.00006443968,0.000007770948,0.00004914104,0.00002368341,0.00004357916,0.9981072,0.00006692422,0.00008067361,0.001112708],"study_design_scores_gemma":[0.00007144462,0.001310339,0.00135287,0.00000717132,0.00004066004,0.0002169548,0.00003261513,0.0005814395,0.9936944,0.00008211565,0.002601435,0.00000857897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875964,0.002647094,0.003651459,0.0003034243,0.000202159,0.0001502418,0.0006790346,0.0002360404,0.004534167],"genre_scores_gemma":[0.9765562,0.004511142,0.00847667,0.0002166566,0.00006578044,0.0004915466,0.001275963,0.00008138829,0.008324687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001575082,"threshold_uncertainty_score":0.00526917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006710529023430663,"score_gpt":0.2134682797579271,"score_spread":0.2067577507344965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}