{"id":"W2074952917","doi":"10.1021/bi0511179","title":"Interaction of LDS-751 and Rhodamine 123 with P-Glycoprotein:  Evidence for Simultaneous Binding of Both Drugs","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Binding site; Rhodamine 123; Chemistry; Rhodamine; Stereochemistry; Biochemistry; ATP-binding cassette transporter; Plasma protein binding; P-glycoprotein; Biophysics; Transporter; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009623048,0.0001072694,0.0002251182,0.00003268178,0.00002331879,0.000003548409,0.00004731199,0.00007835024,0.00002214337],"category_scores_gemma":[0.00006881053,0.00008311968,0.00004783607,0.0000762543,0.00007393723,0.00004206867,0.00000763522,0.00006914698,6.658319e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003364923,"about_ca_system_score_gemma":0.00006173195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001074975,"about_ca_topic_score_gemma":0.000004765071,"domain_scores_codex":[0.9993178,0.000002889589,0.0002167189,0.0001854566,0.0001562127,0.0001208711],"domain_scores_gemma":[0.9994404,0.0001002137,0.0001426759,0.0001646926,0.00009105749,0.00006091408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001232004,0.00008240629,0.0006855993,0.001348762,0.00003874678,0.000006816272,0.0002063877,0.00001306394,0.9904223,0.00000718352,0.00003071182,0.005926031],"study_design_scores_gemma":[0.001056784,0.0002386909,0.0001362172,0.001813558,0.00009568274,0.00002485672,0.0004779223,0.0003945523,0.9952827,0.000004640494,0.0003842422,0.0000901605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99735,0.0008080754,0.001034686,0.0002290534,0.00002661599,0.0002704801,0.00001699859,0.00001805947,0.0002460385],"genre_scores_gemma":[0.9906884,0.0001033734,0.007236687,0.00001915094,0.0001034032,0.00001479331,0.00001943433,0.00001485795,0.001799945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006661638,"threshold_uncertainty_score":0.3389522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807164604936462,"score_gpt":0.2883744632293986,"score_spread":0.270302817180034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}