{"id":"W2074952917","doi":"10.1021/bi0511179","title":"Interaction of LDS-751 and Rhodamine 123 with P-Glycoprotein:  Evidence for Simultaneous Binding of Both Drugs","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Binding site; Rhodamine 123; Chemistry; Rhodamine; Stereochemistry; Biochemistry; ATP-binding cassette transporter; Plasma protein binding; P-glycoprotein; Biophysics; Transporter; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003353121,0.0005054286,0.0007783418,0.0003794316,0.0003792387,0.0006035515,0.0006880879,0.001116561,0.001112308],"category_scores_gemma":[0.0007268033,0.0003755397,0.0006111183,0.0003427707,0.0004443206,0.0005301936,0.0005086726,0.0007530277,0.0006708071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008582576,"about_ca_system_score_gemma":0.0004633839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006117888,"about_ca_topic_score_gemma":0.005746804,"domain_scores_codex":[0.9990525,0.0001466039,0.0000575977,0.0001902357,0.0003228045,0.0002302845],"domain_scores_gemma":[0.9995839,0.0001329041,0.0000679664,0.00005517326,0.00006092103,0.00009922751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007892908,0.00004132629,0.0004352085,0.00003882627,0.00002149286,0.0002213893,0.00003466343,0.00003619055,0.998317,0.000148336,0.00005298618,0.0005736685],"study_design_scores_gemma":[0.00002437825,0.0002972494,0.02117384,0.00001066837,0.00007736545,0.00143435,0.0001153696,0.003850117,0.9710978,0.00006264415,0.001831649,0.00002453583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893406,0.002561553,0.004744825,0.000219064,0.00004263992,0.00004834036,0.0001255496,0.00006587324,0.002851524],"genre_scores_gemma":[0.9941806,0.0004576986,0.003236799,0.0001521522,0.00001259199,0.00003354554,0.0002229518,0.00001596684,0.001687734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006117888,"threshold_uncertainty_score":0.01216453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807164604936462,"score_gpt":0.2883744632293986,"score_spread":0.270302817180034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}