{"id":"W2074955861","doi":"10.1073/pnas.222454899","title":"Glucose is toxic to glycosome-deficient trypanosomes","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Peroxisome; Microbody; Organelle; Biology; Trypanosoma brucei; Biochemistry; Cell biology; Glycolysis; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119189,0.00009112933,0.0001723013,0.0003063956,0.0002059624,0.000025985,0.0006260136,0.00006126799,0.000319253],"category_scores_gemma":[0.0007967458,0.00005837122,0.0001068299,0.001678663,0.000582455,0.0002289728,0.0001617362,0.0001617236,0.00004590685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006476606,"about_ca_system_score_gemma":0.00003064411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002997586,"about_ca_topic_score_gemma":2.852653e-8,"domain_scores_codex":[0.9974705,0.000003172333,0.0003080459,0.000264715,0.001710075,0.0002435041],"domain_scores_gemma":[0.9992069,0.00007573971,0.0001609253,0.0000172665,0.0004033239,0.0001358547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001839642,0.0001801451,0.001875757,0.0000529206,0.00001576231,1.02611e-8,0.0003071601,0.000006107296,0.9496321,0.0200952,0.026167,0.001649452],"study_design_scores_gemma":[0.0003292156,0.0002370944,0.315595,0.0001046469,0.00001361143,0.00003803817,0.0002537694,0.0005923971,0.6639948,0.005132337,0.01361943,0.00008964998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9100018,0.0003458885,8.978593e-7,0.05166508,0.0000128868,0.000366357,0.00003317386,0.00001728759,0.03755659],"genre_scores_gemma":[0.9944346,0.0001134805,0.00118127,0.002005169,0.00008213934,0.00002382368,8.832864e-8,0.000004866667,0.00215457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3137192,"threshold_uncertainty_score":0.3495596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08483450351838775,"score_gpt":0.3506405987749416,"score_spread":0.2658060952565539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}