{"id":"W2074966638","doi":"10.1371/journal.pone.0008603","title":"Intravenously Administered Alphavirus Vector VA7 Eradicates Orthotopic Human Glioma Xenografts in Nude Mice","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"K. Albin Johanssons Stiftelse; Turun Yliopisto; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Luciferase; Oncolytic virus; Alphavirus; Bioluminescence imaging; Semliki Forest virus; Glioma; In vivo; Nude mouse; Virus; Cancer research; Biology; Medicine; Cell culture; Virology; Pathology; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853901,0.0004606968,0.0003350172,0.0003834135,0.0001171643,0.0002562616,0.0002254443,0.0002815089,0.0009172754],"category_scores_gemma":[0.0001037842,0.000104582,0.0002115071,0.0001312598,0.0001892396,0.0001902892,0.0001236163,0.0006200062,0.0004291252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140795,"about_ca_system_score_gemma":0.0002787218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007179487,"about_ca_topic_score_gemma":0.000852161,"domain_scores_codex":[0.999849,0.00001686685,0.00001262871,0.00003124753,0.00004670136,0.00004358021],"domain_scores_gemma":[0.9998795,0.00002288313,0.00002964747,0.00001720203,0.0000191065,0.00003170773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072393,0.000118206,0.0001690153,0.00002683164,0.000006424625,0.00002977961,0.00001392849,0.00004939623,0.9967529,0.00006122512,0.0001027722,0.002562133],"study_design_scores_gemma":[0.00003873219,0.001924424,0.002193147,0.00001131909,0.00002020302,0.0003051169,0.000015132,0.001207908,0.9919556,0.00003070198,0.002294479,0.000003210483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888419,0.002089071,0.005813566,0.00009183974,0.00008398403,0.0001009382,0.0003133232,0.0003318821,0.002333582],"genre_scores_gemma":[0.9890102,0.001148047,0.004591074,0.00004699278,0.00004169683,0.00009121532,0.001078576,0.00007103098,0.003921194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009172754,"threshold_uncertainty_score":0.003068626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742677403192917,"score_gpt":0.2933589378194193,"score_spread":0.2559321637874901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}