{"id":"W2074966638","doi":"10.1371/journal.pone.0008603","title":"Intravenously Administered Alphavirus Vector VA7 Eradicates Orthotopic Human Glioma Xenografts in Nude Mice","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"K. Albin Johanssons Stiftelse; Turun Yliopisto; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Luciferase; Oncolytic virus; Alphavirus; Bioluminescence imaging; Semliki Forest virus; Glioma; In vivo; Nude mouse; Virus; Cancer research; Biology; Medicine; Cell culture; Virology; Pathology; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002570422,0.0002094683,0.0002481944,0.00014058,0.0001032335,0.00004600546,0.0004678553,0.0002397408,0.00026687],"category_scores_gemma":[0.00007873097,0.0002203641,0.00007134907,0.0001956002,0.0001466956,0.0000054621,0.0001137335,0.0003755568,0.00007576385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000193373,"about_ca_system_score_gemma":0.0001166623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008346241,"about_ca_topic_score_gemma":0.003574702,"domain_scores_codex":[0.9983606,0.00010252,0.0002862174,0.0004759988,0.0002925729,0.0004820761],"domain_scores_gemma":[0.9990234,0.0000187952,0.00007379797,0.0006222143,0.00008528213,0.0001764869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005022141,0.001428325,0.005402755,0.00004126842,0.0001360599,0.0000397547,0.0001019549,3.858377e-7,0.9915947,0.00002226269,0.00008252096,0.0006478],"study_design_scores_gemma":[0.001045355,0.002269361,0.006055068,0.00002635109,0.00002370245,0.000008023504,0.00001430455,0.00001093637,0.9893984,0.00005705352,0.0008380078,0.0002534795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982502,0.0003699809,0.000002417422,0.0002997439,0.00006453386,0.0004414486,0.00002735548,0.00002948339,0.0005148174],"genre_scores_gemma":[0.9979931,0.00005777862,0.0004866161,0.0002199892,0.0004377106,0.000110976,0.0001395018,0.00005328961,0.0005010468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491239,"threshold_uncertainty_score":0.8986186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742677403192917,"score_gpt":0.2933589378194193,"score_spread":0.2559321637874901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}