{"id":"W2075026744","doi":"10.1124/jpet.107.134908","title":"Structural Requirements for Activation of the 5-Oxo-6 E,8 Z, 11 Z,14 Z-eicosatetraenoic Acid (5-Oxo-ETE) Receptor: Identification of a Mead Acid Metabolite with Potent Agonist Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute","keywords":"Chemistry; Stereochemistry; Agonist; Receptor; Polymerization; Polymer; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070177,0.0002159741,0.0002028707,0.00009495971,0.0002315775,0.0003349032,0.0002829074,0.0004845271,0.00288786],"category_scores_gemma":[0.0003283704,0.0002022227,0.000258204,0.00006002915,0.0002317381,0.000213141,0.0002298385,0.0003879487,0.0006908667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039684,"about_ca_system_score_gemma":0.0002751451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005055818,"about_ca_topic_score_gemma":0.0007462497,"domain_scores_codex":[0.9998494,0.00003877419,0.00001711069,0.00002200839,0.00003381232,0.00003871617],"domain_scores_gemma":[0.9998161,0.00005471417,0.00004460108,0.00001587356,0.00002296112,0.00004578966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002726316,0.00001995568,0.0001759195,0.0000126386,0.000003472344,0.0001279461,0.00001369042,0.0001971088,0.998243,0.0005455218,0.00001696293,0.000371211],"study_design_scores_gemma":[0.00005453395,0.0003388085,0.003268999,0.000004783445,0.000009587327,0.0006618383,0.00006019279,0.001504597,0.9924333,0.0002271472,0.001427339,0.000008830297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952484,0.0003343083,0.003061684,0.0001268319,0.00001587004,0.00002417023,0.000133575,0.00002413693,0.001031021],"genre_scores_gemma":[0.9970694,0.0001677515,0.001662972,0.00004428824,0.000006288949,0.00001467726,0.0002599593,0.000008184879,0.0007665532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00288786,"threshold_uncertainty_score":0.0096609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03788533037573744,"score_gpt":0.325460130414658,"score_spread":0.2875748000389206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}