{"id":"W2075066807","doi":"10.3747/co.v16i2.428","title":"Development of Cell-Cycle Inhibitors for Cancer Therapy","year":2009,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":244,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cyclin-dependent kinase; Cell cycle; Medicine; Cancer research; Kinase; Cancer; Cancer cell; Palbociclib; Pharmacology; Biology; Cell biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203595,0.000115588,0.0002986018,0.0000886191,0.0000391168,0.000001889838,0.00006321626,0.0001138019,0.00007212385],"category_scores_gemma":[0.00001912436,0.0001024439,0.0000953496,0.0001196885,0.00003761356,0.0000163029,0.00001293288,0.0001426541,0.000007012623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003323193,"about_ca_system_score_gemma":0.0008097124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003047436,"about_ca_topic_score_gemma":0.00001539835,"domain_scores_codex":[0.9991146,0.00001776188,0.0003137357,0.000201116,0.0001284573,0.0002243061],"domain_scores_gemma":[0.9994801,0.00002671541,0.0001337106,0.0001448949,0.0001243556,0.00009019952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003264276,0.0007444726,0.0002229857,0.00005924192,0.0000320592,0.000002535097,0.001135569,0.0000109805,0.2190782,0.00005809883,0.004768003,0.7735614],"study_design_scores_gemma":[0.003551427,0.0007433743,0.001843634,0.00008395271,0.0000358936,0.000004321241,0.00005433514,0.00007255528,0.32787,0.00007122298,0.6655708,0.00009848389],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824527,0.0103027,0.001742949,0.0008314341,0.001770472,0.0009285249,0.00001028884,0.00004604968,0.001914884],"genre_scores_gemma":[0.9899688,0.001221485,0.007720556,0.0003464307,0.0003819978,0.0001827176,0.00004367287,0.00002332613,0.0001109632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.773463,"threshold_uncertainty_score":0.4177543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0859594734008349,"score_gpt":0.4029825135533558,"score_spread":0.3170230401525209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}