{"id":"W2075090387","doi":"10.1053/j.gastro.2008.07.014","title":"A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease","year":2008,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":746,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; London Health Sciences Centre","funders":"National Center for Research Resources; Medical Center, University of Pittsburgh; Vanderbilt University Medical Center; McMaster University; University of Pittsburgh; Cleveland Clinic Foundation; Kaiser Permanente; University of Wisconsin-Madison; Cleveland Clinic; Vanderbilt University","keywords":"Ustekinumab; Crohn's disease; Medicine; Monoclonal antibody; Randomized controlled trial; Monoclonal; Internal medicine; Gastroenterology; Disease; Interleukin 23; Immunology; Antibody; Interleukin; Cytokine; Infliximab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001647983,0.001694282,0.004950353,0.000421323,0.0006304985,0.001414291,0.0008906773,0.002143001,0.006375615],"category_scores_gemma":[0.002395297,0.0008851716,0.001903605,0.0004928643,0.001774225,0.001501603,0.0006807217,0.003635453,0.0009624188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007802232,"about_ca_system_score_gemma":0.001102959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291661,"about_ca_topic_score_gemma":0.002284923,"domain_scores_codex":[0.9991413,0.000469168,0.00006453505,0.0001397114,0.00004257797,0.0001427014],"domain_scores_gemma":[0.9987246,0.0003927305,0.0001929656,0.0001037204,0.00006333705,0.0005225277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9948729,0.0009510046,0.0003778074,0.0001391197,0.0004135717,0.00002156847,0.00001500487,0.0001017691,0.000550401,0.0000470968,0.0001807656,0.002329108],"study_design_scores_gemma":[0.9782525,0.01963137,0.001099658,0.00001314996,0.0003814442,0.00002041404,0.0000196751,0.0001925901,0.0001047896,0.00007916736,0.0001965728,0.000008571971],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881391,0.00429177,0.0005325942,0.001412017,0.001298501,0.001471299,0.0006472455,0.0001014431,0.002106054],"genre_scores_gemma":[0.9918969,0.001682472,0.0007665182,0.001290636,0.0005955667,0.001248664,0.0007689266,0.00001812165,0.001732306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006375615,"threshold_uncertainty_score":0.02132857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007392290025929885,"score_gpt":0.2343504618381705,"score_spread":0.2269581718122406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}