{"id":"W2075092043","doi":"10.1099/vir.0.80466-0","title":"Role of the protein kinase PKR in the inhibition of varicella-zoster virus replication by beta interferon and gamma interferon","year":2004,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alfried Krupp von Bohlen und Halbach-Stiftung; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Protein kinase R; Virology; Biology; Interferon; Viral replication; Varicella zoster virus; Virus; Herpes simplex virus; Protein kinase A; EIF-2 kinase; Phosphorylation; Antiviral protein; In vitro; RNA; Cell biology; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002730437,0.000074268,0.0001218099,0.00004465379,0.00001986124,0.000006222828,0.0001365423,0.00009430644,0.000008433599],"category_scores_gemma":[0.00003163112,0.00004585558,0.00006920652,0.00005724771,0.0001035371,0.00000747657,0.00005465337,0.00009297233,2.807949e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001339997,"about_ca_system_score_gemma":0.00003723477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003745804,"about_ca_topic_score_gemma":0.00005079505,"domain_scores_codex":[0.999199,0.0001571247,0.0003528951,0.0001160921,0.00009337565,0.00008154185],"domain_scores_gemma":[0.9993131,0.000005757833,0.0003518672,0.0002311189,0.00006893526,0.00002925708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005684539,0.0001284868,0.001053161,0.000008856995,0.00001380661,8.80001e-7,0.0001102137,0.0001331945,0.9966018,0.0001790828,0.000209388,0.000992669],"study_design_scores_gemma":[0.001092533,0.001110375,0.03115396,0.00002284857,0.00002287763,0.0000426794,0.0000619031,0.00003205692,0.9644963,0.000893464,0.001017989,0.00005300124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974016,0.0008138721,0.0002763031,0.001212922,0.00003106444,0.0001486109,0.000007551504,6.302728e-7,0.00010747],"genre_scores_gemma":[0.9993096,0.00004834007,0.00008692042,0.0004153899,0.00006597741,0.00000516096,0.000009539991,0.000005703012,0.00005337495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03210549,"threshold_uncertainty_score":0.1869936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005783940467819693,"score_gpt":0.2269406658197625,"score_spread":0.2211567253519429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}