{"id":"W2075122875","doi":"10.1074/jbc.m109.078980","title":"Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Waterloo; University of Toronto; Ontario Institute for Cancer Research","funders":"Division of Materials Research; National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Teva Pharmaceutical Industries; Heart and Stroke Foundation of Canada; National Institutes of Health; National Science Foundation","keywords":"Oligosaccharide; Chemistry; Hydrolase; Enzyme; Hydrolysis; Stereochemistry; Biochemistry; Active site; Substrate (aquarium); Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183826,0.0002241959,0.0002860498,0.00008967044,0.0001386882,0.0003695512,0.0003323092,0.0003368059,0.00134397],"category_scores_gemma":[0.0002330938,0.0001687758,0.0002366335,0.00009391993,0.0001903692,0.0001826099,0.0001652231,0.0002561346,0.0005665575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003001616,"about_ca_system_score_gemma":0.0001905813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007338519,"about_ca_topic_score_gemma":0.0008520985,"domain_scores_codex":[0.9998944,0.00001950358,0.000009292592,0.00002912707,0.0000273743,0.00002024853],"domain_scores_gemma":[0.9998978,0.00001936601,0.00002543814,0.000007576784,0.00001654111,0.00003323161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009263927,0.00007337202,0.005357009,0.00009460796,0.00002777776,0.0006498237,0.0001396236,0.0008368064,0.9855149,0.0008715956,0.0004594033,0.005048819],"study_design_scores_gemma":[0.0004528415,0.0006884414,0.1082256,0.00003290305,0.0001064472,0.008798753,0.0003027752,0.01897109,0.848901,0.001440702,0.01201452,0.00006487134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964885,0.0009610967,0.001223771,0.00008912951,0.00001122469,0.00000909192,0.0001503416,0.00004182562,0.00102503],"genre_scores_gemma":[0.9973236,0.0002456437,0.001187245,0.00007255385,0.000005899326,0.000008480701,0.0005009074,0.000009110351,0.0006465116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00134397,"threshold_uncertainty_score":0.004496038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572211879389807,"score_gpt":0.2887198256595704,"score_spread":0.2729977068656723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}