{"id":"W2075131602","doi":"10.1016/j.bbrc.2011.08.011","title":"Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide","year":2011,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Excitotoxicity; Sterol regulatory element-binding protein; Amyotrophic lateral sclerosis; Glutamatergic; Glutamate receptor; Neuroprotection; Cell biology; Chemistry; Spinal cord; Neuroscience; Biology; Biochemistry; Transcription factor; Internal medicine; Medicine; Receptor; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002587186,0.00035892,0.000438365,0.0002812098,0.0002833034,0.0003439116,0.0004647683,0.0005301557,0.0009653924],"category_scores_gemma":[0.0002100499,0.0002201078,0.0001600317,0.0001953833,0.0004368174,0.0003949647,0.0002640137,0.001006897,0.0002078625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004418968,"about_ca_system_score_gemma":0.0003377715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004147255,"about_ca_topic_score_gemma":0.000750664,"domain_scores_codex":[0.9999422,0.00001709091,0.000005156593,0.000007878778,0.000009804513,0.00001793734],"domain_scores_gemma":[0.9999517,0.00001143593,0.00001014679,0.000003955915,0.000004501831,0.00001824085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01120822,0.0003728379,0.0005604977,0.000460939,0.0000479067,0.001188154,0.00008697862,0.000579824,0.9464754,0.001238411,0.0009075878,0.03687321],"study_design_scores_gemma":[0.001524875,0.005900222,0.008017512,0.00006653349,0.0002665773,0.005565373,0.0001753777,0.002655507,0.9645624,0.001057103,0.01017093,0.0000376038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783946,0.01643203,0.001615719,0.0007375508,0.00008010952,0.00003473819,0.0001857222,0.00008517674,0.002434305],"genre_scores_gemma":[0.987862,0.007615299,0.002028839,0.0001333301,0.00006446987,0.00007908617,0.0002237792,0.00001940261,0.001973811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009653924,"threshold_uncertainty_score":0.003229558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08065350115102615,"score_gpt":0.3188053915015431,"score_spread":0.2381518903505169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}