{"id":"W2075146969","doi":"10.1016/j.bmc.2010.05.078","title":"A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: Synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK","keywords":"Trypanosoma brucei; Chemistry; Leishmania donovani; Plasmodium falciparum; Leishmania mexicana; In vivo; Stereochemistry; Cytotoxic T cell; Antiprotozoal; Chemical synthesis; In vitro; Leishmania major; DNA; Protozoa; Biochemistry; Kinetoplastida; Leishmania; Leishmaniasis; Biology; Parasite hosting; Protozoal disease; Immunology; Microbiology; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007247696,0.0001940257,0.0002911115,0.00003570459,0.00007024388,0.00001844987,0.0001615657,0.000143014,0.0001047477],"category_scores_gemma":[0.0002636625,0.0001495116,0.0000522224,0.0001141439,0.0003745272,0.000007672749,0.00006946405,0.0002709048,5.23929e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002563103,"about_ca_system_score_gemma":0.0001882985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001822288,"about_ca_topic_score_gemma":0.0002530926,"domain_scores_codex":[0.9988102,0.00004262793,0.0003122888,0.0003744789,0.0002420318,0.0002184122],"domain_scores_gemma":[0.9992542,0.00006526546,0.0001664291,0.0003274659,0.0001006425,0.00008605361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002088383,0.0002012797,0.000728394,0.00007269078,0.00007513052,0.000001521014,0.0001048052,2.983858e-7,0.9959112,0.00007208102,0.00004307779,0.002580623],"study_design_scores_gemma":[0.005171826,0.00004902224,0.003067229,0.00007868746,0.0001815874,0.0001841339,0.0003187334,0.000291426,0.9892501,0.0001048903,0.001131245,0.0001711848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966952,0.001652744,0.0001830837,0.0006204268,0.0002181938,0.0002509708,0.00003462126,0.00000652263,0.0003382344],"genre_scores_gemma":[0.9984288,0.0007651572,0.0001354878,0.0002025579,0.0003371704,0.00004247046,0.00001974907,0.00002160079,0.00004695961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006661226,"threshold_uncertainty_score":0.6096908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264596729647956,"score_gpt":0.2784362683810141,"score_spread":0.2657903010845346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}