{"id":"W2075146969","doi":"10.1016/j.bmc.2010.05.078","title":"A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: Synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK","keywords":"Trypanosoma brucei; Chemistry; Leishmania donovani; Plasmodium falciparum; Leishmania mexicana; In vivo; Stereochemistry; Cytotoxic T cell; Antiprotozoal; Chemical synthesis; In vitro; Leishmania major; DNA; Protozoa; Biochemistry; Kinetoplastida; Leishmania; Leishmaniasis; Biology; Parasite hosting; Protozoal disease; Immunology; Microbiology; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008574157,0.0001927649,0.0001578883,0.0001787731,0.00009800375,0.0001326008,0.0002995569,0.0001927875,0.001664586],"category_scores_gemma":[0.0001087822,0.00007667949,0.00009424201,0.0001878202,0.0001462323,0.00014436,0.0001146738,0.0003093244,0.0002879029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002062206,"about_ca_system_score_gemma":0.0002049252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009057956,"about_ca_topic_score_gemma":0.001177343,"domain_scores_codex":[0.9999425,0.00001248813,0.000003970975,0.00001012148,0.0000115791,0.00001934871],"domain_scores_gemma":[0.9999429,0.00000669114,0.00001236891,0.000007014937,0.000005473126,0.00002545564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003245503,0.00005818644,0.0001555087,0.00007822057,0.00000560346,0.000147883,0.0000234398,0.0003269594,0.9880599,0.0004645086,0.0001445383,0.01021067],"study_design_scores_gemma":[0.00009174091,0.002152228,0.001525778,0.000006148158,0.0000164495,0.0005459948,0.00001587328,0.0005468877,0.9852358,0.00004614528,0.009807817,0.00000912403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977459,0.004201633,0.006128678,0.0001462891,0.00005597961,0.0001508305,0.0007595064,0.000150187,0.01094802],"genre_scores_gemma":[0.9928404,0.0009409386,0.002841414,0.00006086407,0.000008254749,0.00003863202,0.0004714385,0.000008535566,0.002789463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001664586,"threshold_uncertainty_score":0.005568564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264596729647956,"score_gpt":0.2784362683810141,"score_spread":0.2657903010845346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}