{"id":"W2075205566","doi":"10.1371/journal.pgen.1002928","title":"Genomics of Adaptation during Experimental Evolution of the Opportunistic Pathogen Pseudomonas aeruginosa","year":2012,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Carleton University; University of Ottawa","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Biology; Experimental evolution; Adaptation (eye); Pseudomonas aeruginosa; DNA gyrase; Genetics; Pathogen; Antibiotic resistance; Host adaptation; Microbiology; Gene; Comparative genomics; Human pathogen; Mutation; Genome; Antibiotics; Genomics; Bacteria; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003590492,0.0001944374,0.0002102348,0.0002144947,0.0002558161,0.0003251087,0.0003089846,0.0005014964,0.0004743718],"category_scores_gemma":[0.0007292131,0.0001712184,0.0002484778,0.0002481967,0.0004605376,0.0002306516,0.0006434323,0.0008490224,0.00008746904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006903645,"about_ca_system_score_gemma":0.0002891611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00118005,"about_ca_topic_score_gemma":0.001984537,"domain_scores_codex":[0.999708,0.00009948297,0.00002021526,0.00005960449,0.00006482804,0.00004782956],"domain_scores_gemma":[0.9996494,0.0001778241,0.00007066469,0.00004397951,0.00002151646,0.00003656884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000119969,0.00006563815,0.002470749,0.00002776065,0.00001353049,0.00007346351,0.0000865351,0.0006523321,0.9928398,0.0003942095,0.00003322717,0.003222653],"study_design_scores_gemma":[0.000107308,0.002344772,0.4940969,0.00005203813,0.0001138263,0.001769231,0.0009555039,0.02129818,0.4687756,0.00264412,0.007734192,0.0001083445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973782,0.0001447899,0.001564123,0.0001028785,0.000006124667,0.00001484261,0.0001603829,0.00001861893,0.0006100971],"genre_scores_gemma":[0.9956044,0.0002639441,0.002750693,0.0001464062,0.000007323758,0.0000757212,0.0005158474,0.00004220714,0.0005934825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118005,"threshold_uncertainty_score":0.005008996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167153321204266,"score_gpt":0.2272879510139503,"score_spread":0.2105726188935237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}