{"id":"W2075231932","doi":"10.1038/ncomms3388","title":"HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Myogenesis; Translation (biology); Gene silencing; Cell biology; HMGB1; Messenger RNA; microRNA; RNA-binding protein; Three prime untranslated region; Myocyte; Protein biosynthesis; Argonaute; Chemistry; Biology; Untranslated region; RNA; Small interfering RNA; Molecular biology; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757229,0.00007408898,0.00007189115,0.00002592444,0.0001939784,0.00001630572,0.0004667021,0.0001454071,0.00001350542],"category_scores_gemma":[0.0001659037,0.00005841789,0.00002701444,0.0001532674,0.0001780369,0.00001058055,0.0001504165,0.000225399,0.000002745051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000576489,"about_ca_system_score_gemma":0.00002249802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003026838,"about_ca_topic_score_gemma":0.00003764336,"domain_scores_codex":[0.9993381,0.0001307586,0.0001642873,0.0001545596,0.0001068393,0.0001054765],"domain_scores_gemma":[0.9984131,0.00007728022,0.00008428899,0.001180319,0.000213617,0.00003136754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005931516,0.00002750897,0.0005224968,0.00000902396,0.00002689333,9.533684e-9,0.000100871,0.00004722692,0.9543271,0.0006253226,0.002494938,0.0418127],"study_design_scores_gemma":[0.0005634245,0.00009561099,0.0374823,0.00002605152,0.00003746739,0.000009904687,0.0002944751,0.003258675,0.6630785,0.001761463,0.2930699,0.0003222248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8694833,0.08437951,0.002080769,0.03788508,0.00008789961,0.001262787,0.00008983786,0.00003618549,0.004694663],"genre_scores_gemma":[0.988739,0.001883665,0.008522767,0.0001352599,0.00002667087,0.00005041212,0.0002176813,0.00001303956,0.0004114761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2912486,"threshold_uncertainty_score":0.2382212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195901283409671,"score_gpt":0.3154848019375767,"score_spread":0.2958946735966096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}