{"id":"W2075231932","doi":"10.1038/ncomms3388","title":"HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Myogenesis; Translation (biology); Gene silencing; Cell biology; HMGB1; Messenger RNA; microRNA; RNA-binding protein; Three prime untranslated region; Myocyte; Protein biosynthesis; Argonaute; Chemistry; Biology; Untranslated region; RNA; Small interfering RNA; Molecular biology; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903795,0.0003473283,0.0003133591,0.0003265783,0.0004551924,0.0007108255,0.000255322,0.0003452591,0.002294855],"category_scores_gemma":[0.0002710295,0.000344574,0.0003798257,0.0001503017,0.000374794,0.0002865414,0.0005789249,0.0006149483,0.000832518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005928325,"about_ca_system_score_gemma":0.0003371287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007267195,"about_ca_topic_score_gemma":0.002353942,"domain_scores_codex":[0.9997126,0.00004039442,0.00002220451,0.00006437711,0.00007471636,0.00008572239],"domain_scores_gemma":[0.9998659,0.00002097526,0.00003495708,0.00001205086,0.00002187442,0.00004418138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005546179,0.00002912247,0.0006323373,0.00004528455,0.00001628033,0.00007861748,0.00003053558,0.00007277769,0.9941842,0.0005223633,0.00031219,0.003521679],"study_design_scores_gemma":[0.00009626558,0.0003182479,0.01503495,0.00001523951,0.00005151871,0.000211841,0.0001363761,0.002471467,0.9737324,0.0004740342,0.007442671,0.00001507682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740195,0.007160944,0.005652599,0.0008493299,0.0005512866,0.0000514697,0.0007479957,0.0004281289,0.01053879],"genre_scores_gemma":[0.9898126,0.0008653942,0.002431241,0.0002363982,0.00006875119,0.00003413329,0.0004939419,0.00009076681,0.005966774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294855,"threshold_uncertainty_score":0.007677078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195901283409671,"score_gpt":0.3154848019375767,"score_spread":0.2958946735966096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}