{"id":"W2075238581","doi":"10.1021/nn2039643","title":"Poly-<scp>l</scp>-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery","year":2012,"lang":"en","type":"article","venue":"ACS Nano","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Materials science; Nanoparticle; Biocompatibility; Surface modification; Mesoporous silica; Silicon dioxide; HeLa; Gene delivery; Thermogravimetric analysis; Nanotechnology; Chemical engineering; Mesoporous material; Chemistry; Organic chemistry; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346951,0.0002710857,0.0002812043,0.00009046085,0.0002449421,0.00002965009,0.0001806737,0.0002490888,0.000009179672],"category_scores_gemma":[0.0002531056,0.000232779,0.0002282905,0.000245075,0.0001062056,0.00001635674,0.0001076791,0.00007351647,0.000008283323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003011713,"about_ca_system_score_gemma":0.00007068492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002142752,"about_ca_topic_score_gemma":0.00001765386,"domain_scores_codex":[0.9984367,0.00005993014,0.0002954659,0.0004151516,0.0001913054,0.0006014199],"domain_scores_gemma":[0.998948,0.00004393998,0.0001625811,0.0004489915,0.000205926,0.0001905432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007465436,0.00008867981,0.001325575,0.00001143662,0.0001714547,0.000001143385,0.00003808028,0.000001454787,0.9904934,0.0001291745,0.005682032,0.001982926],"study_design_scores_gemma":[0.0005943458,0.0001808875,0.0004084282,0.000007053818,0.0001164686,0.00002610748,0.0001213202,0.00001326286,0.8177828,0.000165496,0.1804504,0.000133408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916133,0.006324144,0.0009844537,0.0001057128,0.0001740006,0.0002902197,0.0001723291,0.00009051122,0.0002452809],"genre_scores_gemma":[0.9873416,0.000229231,0.008122875,0.0007260576,0.0003869287,0.00004254618,0.001069429,0.000041378,0.002039957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1747683,"threshold_uncertainty_score":0.949245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009626338416064422,"score_gpt":0.2620444654862145,"score_spread":0.2524181270701501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}