{"id":"W2075238581","doi":"10.1021/nn2039643","title":"Poly-<scp>l</scp>-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery","year":2012,"lang":"en","type":"article","venue":"ACS Nano","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Materials science; Nanoparticle; Biocompatibility; Surface modification; Mesoporous silica; Silicon dioxide; HeLa; Gene delivery; Thermogravimetric analysis; Nanotechnology; Chemical engineering; Mesoporous material; Chemistry; Organic chemistry; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001028961,0.0002486244,0.0001446839,0.0001231884,0.00008059994,0.0001599737,0.000155491,0.0003051828,0.00037559],"category_scores_gemma":[0.000116313,0.0001108126,0.0001883075,0.00008919585,0.0001894219,0.0001928252,0.0001148282,0.0001912239,0.0002925296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003602008,"about_ca_system_score_gemma":0.0002000781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005939925,"about_ca_topic_score_gemma":0.001114509,"domain_scores_codex":[0.9999266,0.00001006285,0.000006361846,0.00001959934,0.00002471267,0.00001278252],"domain_scores_gemma":[0.9999009,0.00002065118,0.00003530905,0.000006244036,0.0000206403,0.00001619933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001734994,0.000003581048,0.00004515514,0.00002041283,0.000002082104,0.00001908254,0.000002739549,0.000166127,0.9990382,0.00003099607,0.00001670242,0.0006376656],"study_design_scores_gemma":[0.000007766397,0.0001000206,0.0008459448,0.000001782099,0.000006014815,0.00008236623,0.000004876341,0.002213188,0.9957795,0.00002014982,0.000932668,0.000005742103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800802,0.001527907,0.01587641,0.00009959717,0.00003851431,0.0000596996,0.0001881078,0.0002320072,0.001897546],"genre_scores_gemma":[0.9890283,0.0003721492,0.008773873,0.00006801836,0.00001137934,0.0000337931,0.0001609997,0.00002206521,0.001529328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005939925,"threshold_uncertainty_score":0.002613485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009626338416064422,"score_gpt":0.2620444654862145,"score_spread":0.2524181270701501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}