{"id":"W2075360086","doi":"10.4161/isl.29236","title":"Overexpression of PAX4 reduces glucagon expression in differentiating hESCs","year":2014,"lang":"en","type":"article","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"PAX4; Glucagon; Biology; Embryonic stem cell; Progenitor cell; Enteroendocrine cell; Cell biology; Cellular differentiation; Stem cell; Internal medicine; Insulin; Endocrinology; Transcription factor; Endocrine system; Hormone; Homeobox; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002674471,0.0003623283,0.0002753182,0.0002748129,0.0001356763,0.0003865632,0.0002451791,0.0002559501,0.001248294],"category_scores_gemma":[0.0001894221,0.0002091583,0.0002614734,0.0001608419,0.0002651582,0.0002656385,0.0003607699,0.0005530313,0.0002343051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002399535,"about_ca_system_score_gemma":0.0002501095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004205842,"about_ca_topic_score_gemma":0.0004396568,"domain_scores_codex":[0.9997281,0.00004069471,0.00004967482,0.00005744766,0.00007751778,0.00004659687],"domain_scores_gemma":[0.9997774,0.00007371628,0.00005505352,0.00002905635,0.00002113639,0.00004372529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004201601,0.00001757193,0.0001038841,0.00001952825,0.000004424052,0.00002189325,0.00001189608,0.00006037567,0.999116,0.00006556693,0.000008874485,0.000527863],"study_design_scores_gemma":[0.000004600596,0.00007544848,0.0006934769,0.000001633795,0.000008131923,0.00003368085,0.00001356559,0.0003270931,0.9981908,0.00001184302,0.0006383861,0.000001270114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943991,0.0004936018,0.003577401,0.0000469702,0.00002910186,0.0000330592,0.0001514569,0.00006754671,0.001201798],"genre_scores_gemma":[0.9916787,0.0005334225,0.00345215,0.00003922881,0.000008866214,0.00006228004,0.0003466941,0.00004934887,0.003829395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248294,"threshold_uncertainty_score":0.004175961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324254441710856,"score_gpt":0.2587918621434159,"score_spread":0.2455493177263073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}