{"id":"W2075360086","doi":"10.4161/isl.29236","title":"Overexpression of PAX4 reduces glucagon expression in differentiating hESCs","year":2014,"lang":"en","type":"article","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"PAX4; Glucagon; Biology; Embryonic stem cell; Progenitor cell; Enteroendocrine cell; Cell biology; Cellular differentiation; Stem cell; Internal medicine; Insulin; Endocrinology; Transcription factor; Endocrine system; Hormone; Homeobox; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128205,0.00008557678,0.0002342617,0.00008564461,0.00002345557,0.00000514793,0.0000402527,0.00006858895,0.0002172495],"category_scores_gemma":[0.0003924588,0.00006287287,0.00004710732,0.00008333972,0.0000240125,0.00004895727,0.00002931909,0.00009075255,0.00001535196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001717083,"about_ca_system_score_gemma":0.00001434152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001507024,"about_ca_topic_score_gemma":3.154722e-7,"domain_scores_codex":[0.9992524,0.00005838111,0.0002221433,0.0001500007,0.0001812168,0.0001358547],"domain_scores_gemma":[0.9995034,0.0001337668,0.00009236071,0.0001814149,0.00002792083,0.00006111871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008704943,0.0001280554,0.01757412,0.0000748596,0.000004256283,9.409457e-7,0.0001679809,0.000003554191,0.9756699,0.00004609831,0.0006653552,0.005577803],"study_design_scores_gemma":[0.001228449,0.0001461443,0.08812322,0.001304783,0.00001188441,0.000001526249,0.00007346072,0.0006748093,0.9073912,0.0001642843,0.0008151354,0.00006512526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871281,0.0001019907,0.00009266201,0.0001158161,0.0001505425,0.00009785919,0.000001248983,0.00002924996,0.01228248],"genre_scores_gemma":[0.9986165,0.00001099724,0.000745695,0.0001512652,0.00009854019,0.000007509426,0.000009891571,0.000009672021,0.0003499376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07054909,"threshold_uncertainty_score":0.2563882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324254441710856,"score_gpt":0.2587918621434159,"score_spread":0.2455493177263073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}