{"id":"W2075365683","doi":"10.1074/jbc.275.8.5323","title":"5′-Nicked Apurinic/Apyrimidinic Sites Are Resistant to β-Elimination by β-Polymerase and Are Persistent in Human Cultured Cells after Oxidative Stress","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences","keywords":"AP site; Oxidative stress; Polymerase; Chemistry; Oxidative phosphorylation; Molecular biology; Oxidative damage; Cell biology; Biology; Biochemistry; DNA damage; DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048444,0.0002184254,0.0003075485,0.00002727458,0.00005509964,0.00003258924,0.0002164307,0.0003127044,0.0002520012],"category_scores_gemma":[0.00009805999,0.0001669696,0.000173659,0.00008244537,0.00009306508,0.000008190175,0.00008169026,0.0002119009,0.000002554176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004992047,"about_ca_system_score_gemma":0.00001894567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002313584,"about_ca_topic_score_gemma":0.00000554259,"domain_scores_codex":[0.9986951,0.00008153297,0.0004478194,0.0003612982,0.0001676745,0.0002466127],"domain_scores_gemma":[0.99919,0.0000194899,0.0002939921,0.0001906617,0.0001032675,0.0002025844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006743473,0.0002398632,0.001267764,0.0000367289,0.00004460377,0.00005269054,0.00007438428,0.00001142097,0.9965837,4.535501e-7,0.0007386998,0.0002753678],"study_design_scores_gemma":[0.0006814456,0.0006081384,0.002839577,0.0001059704,0.00002721262,0.00002978795,0.000837216,0.000004243636,0.9934925,0.00001767928,0.001132158,0.000224033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997128,0.002170687,0.000007532376,0.0002619366,0.00002238919,0.0001084964,0.00009563786,0.000006249938,0.00019914],"genre_scores_gemma":[0.9980561,0.0004215961,0.0002880309,0.0002142044,0.0001286174,0.00001269875,0.00006155558,0.00001245936,0.0008047702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003091138,"threshold_uncertainty_score":0.6808823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224284711685563,"score_gpt":0.2418406820596308,"score_spread":0.2295978349427752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}