{"id":"W2075428150","doi":"10.2147/cpaa.s64131","title":"Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug–drug interaction study","year":2014,"lang":"en","type":"article","venue":"Clinical Pharmacology Advances and Applications","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Valeant Pharmaceuticals International","keywords":"Digoxin; Pharmacokinetics; Pharmacology; Therapeutic index; Medicine; Active metabolite; Tolerability; Chemistry; Metabolite; Oral administration; Urine; Drug; Endocrinology; Internal medicine; Adverse effect; Heart failure","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009085233,0.0001160388,0.0003100097,0.00004345712,0.000038997,0.000001729272,0.0001601323,0.00007128577,0.00001456074],"category_scores_gemma":[0.00009180707,0.00008455335,0.00007314034,0.0001303152,0.000258311,0.000006035548,0.00004217448,0.0001704323,0.000001276066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000407898,"about_ca_system_score_gemma":0.00001712279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001980397,"about_ca_topic_score_gemma":0.00004683503,"domain_scores_codex":[0.9983813,0.0003552466,0.000767403,0.0002978742,0.00009379513,0.0001044456],"domain_scores_gemma":[0.9983082,0.0009051659,0.00046118,0.0002102825,0.00006954296,0.00004566209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01991906,0.008936843,0.4687976,0.0006300071,0.0007394517,8.686353e-7,0.001533015,0.008485571,0.3559794,0.0005341357,0.007228892,0.1272152],"study_design_scores_gemma":[0.02459274,0.006175961,0.1746021,0.0001345989,0.0005803439,0.000001175479,0.0006896153,0.001373791,0.5378836,0.001315169,0.2521516,0.00049926],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997116,0.0003933408,0.0004124575,0.0009150814,0.0001788838,0.0007786066,0.0001089059,0.000004494938,0.00009217433],"genre_scores_gemma":[0.9978083,0.001297839,0.00008200905,0.0001977705,0.000255805,0.0001348464,0.0001808199,0.00000848747,0.00003407627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2941955,"threshold_uncertainty_score":0.3447985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03965912287957619,"score_gpt":0.4228351740351939,"score_spread":0.3831760511556178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}