{"id":"W2075428150","doi":"10.2147/cpaa.s64131","title":"Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug–drug interaction study","year":2014,"lang":"en","type":"article","venue":"Clinical Pharmacology Advances and Applications","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Valeant Pharmaceuticals International","keywords":"Digoxin; Pharmacokinetics; Pharmacology; Therapeutic index; Medicine; Active metabolite; Tolerability; Chemistry; Metabolite; Oral administration; Urine; Drug; Endocrinology; Internal medicine; Adverse effect; Heart failure","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001666713,0.0003798032,0.0009765262,0.0002320669,0.0003098625,0.0003843822,0.0002093684,0.0004409666,0.002061153],"category_scores_gemma":[0.001097289,0.0002204117,0.000683807,0.0002004709,0.0003155079,0.0003899909,0.0002402566,0.0004751185,0.0003763274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898935,"about_ca_system_score_gemma":0.0003502851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182347,"about_ca_topic_score_gemma":0.002285675,"domain_scores_codex":[0.9991564,0.0003265875,0.00006991765,0.0001773664,0.0001964827,0.00007329367],"domain_scores_gemma":[0.9992225,0.0002225183,0.0001995981,0.00007219628,0.00007156016,0.000211488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.329379,0.02377898,0.3360335,0.0005347679,0.005288142,0.00171571,0.001231531,0.0006967115,0.1942544,0.0001843416,0.0008577688,0.1060452],"study_design_scores_gemma":[0.007002336,0.2196493,0.7501586,0.0000182364,0.002734027,0.001750389,0.0002559579,0.00143872,0.01387036,0.00008438168,0.002986388,0.00005129882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992208,0.0002556239,0.0001103228,0.00002040872,0.00000396924,0.00004061011,0.00007408558,0.000004885281,0.0002692809],"genre_scores_gemma":[0.9991109,0.0001187305,0.0001738674,0.00006217662,0.00001026014,0.00001757068,0.0001197245,0.00000277954,0.0003839652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061153,"threshold_uncertainty_score":0.008814514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03965912287957619,"score_gpt":0.4228351740351939,"score_spread":0.3831760511556178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}