{"id":"W2075428157","doi":"10.1371/journal.ppat.1002468","title":"Human Subtilase SKI-1/S1P Is a Master Regulator of the HCV Lifecycle and a Potential Host Cell Target for Developing Indirect-Acting Antiviral Agents","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biology; Sterol regulatory element-binding protein; Cell biology; Hepatitis C virus; Lipid droplet; Viral replication; Lipid metabolism; Virology; Virus; Transcription factor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003679722,0.0001805644,0.0003439884,0.0001229975,0.0002266405,0.00002961884,0.0001233802,0.0001204859,0.00008549433],"category_scores_gemma":[0.0001762114,0.0001416958,0.0001324355,0.0001941405,0.00009746849,0.0001442771,0.0001964939,0.0001919039,0.00001338784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006882693,"about_ca_system_score_gemma":0.0001069653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001417101,"about_ca_topic_score_gemma":0.000004618504,"domain_scores_codex":[0.9982857,0.00009632434,0.0003331038,0.0002652897,0.0004489617,0.000570592],"domain_scores_gemma":[0.9991612,0.00004627305,0.0001579294,0.0003286613,0.0001339096,0.0001720474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006956817,0.0002305653,0.4732512,0.0004781796,0.00009763319,0.00001396176,0.002314128,1.520618e-7,0.5206845,0.00001429925,0.0005270334,0.002318719],"study_design_scores_gemma":[0.001952525,0.0002096792,0.2472409,0.0003298064,0.0001746098,0.000006397892,0.0002588095,0.0005127339,0.742821,0.00002356766,0.006195635,0.0002743791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964182,0.0001034387,0.0001524014,0.0002318608,0.0001175685,0.0009386987,0.0002002841,0.00002710399,0.001810492],"genre_scores_gemma":[0.995062,0.00001347427,0.003514239,0.0002790242,0.0002639636,0.00005007908,0.00001885563,0.00005754838,0.0007408206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2260103,"threshold_uncertainty_score":0.5778187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07007307938946224,"score_gpt":0.3102140761570134,"score_spread":0.2401409967675512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}