{"id":"W2075428157","doi":"10.1371/journal.ppat.1002468","title":"Human Subtilase SKI-1/S1P Is a Master Regulator of the HCV Lifecycle and a Potential Host Cell Target for Developing Indirect-Acting Antiviral Agents","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biology; Sterol regulatory element-binding protein; Cell biology; Hepatitis C virus; Lipid droplet; Viral replication; Lipid metabolism; Virology; Virus; Transcription factor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009308138,0.0003339878,0.0002544981,0.0002012922,0.0001127925,0.0002230288,0.00009348113,0.0001606709,0.0009232418],"category_scores_gemma":[0.00006958657,0.00008117304,0.0001827944,0.0001236478,0.0001746272,0.0001023235,0.0001322682,0.0003336224,0.0004225604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244843,"about_ca_system_score_gemma":0.0002177928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003515194,"about_ca_topic_score_gemma":0.0004571303,"domain_scores_codex":[0.9999526,0.000007169857,0.000004943978,0.000009310661,0.00001405674,0.0000120504],"domain_scores_gemma":[0.999947,0.000008497764,0.00002010054,0.000004411849,0.00000519832,0.00001475695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002460669,0.00001709437,0.0005098079,0.00006299074,0.000005359903,0.00007519042,0.000006506963,0.00009492822,0.9944088,0.00008771726,0.00006863994,0.004416834],"study_design_scores_gemma":[0.00001824097,0.0003727505,0.004774333,0.000008157781,0.00001687553,0.000555338,0.00001061443,0.0007058813,0.9889031,0.00005747885,0.004573129,0.000004055468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700795,0.02042824,0.005282705,0.0003712266,0.00006888057,0.00005472758,0.0008116892,0.0001742292,0.002728815],"genre_scores_gemma":[0.9877355,0.005913519,0.002614177,0.0000698181,0.00003276606,0.00002994789,0.001297775,0.00001841281,0.002288126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009232418,"threshold_uncertainty_score":0.003088593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07007307938946224,"score_gpt":0.3102140761570134,"score_spread":0.2401409967675512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}