{"id":"W2075429778","doi":"10.1098/rspb.2014.0566","title":"The path of least resistance: aggressive or moderate treatment?","year":2014,"lang":"en","type":"article","venue":"Proceedings of the Royal Society B Biological Sciences","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council","keywords":"Intensive care medicine; Drug resistance; Dose; Resistance (ecology); Resistance Factors; Medicine; Drug; Path (computing); Risk analysis (engineering); Biology; Computer science; Pharmacology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005326081,0.0005299084,0.001689671,0.0006000855,0.0009049916,0.00416629,0.001169819,0.003721268,0.003941889],"category_scores_gemma":[0.01138107,0.0003130531,0.0006529481,0.0006071745,0.006009113,0.005665361,0.002313092,0.005809664,0.001102872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002011583,"about_ca_system_score_gemma":0.002574834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000916229,"about_ca_topic_score_gemma":0.00160798,"domain_scores_codex":[0.9971002,0.001432825,0.0002605641,0.0004017144,0.0004931498,0.0003115362],"domain_scores_gemma":[0.9948884,0.002305639,0.001087559,0.0003328781,0.0005292504,0.0008564069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001996169,0.0005631775,0.01819786,0.006700405,0.0008311321,0.001199558,0.003037495,0.002482061,0.01706607,0.2568314,0.06734197,0.6237527],"study_design_scores_gemma":[0.0004038034,0.002560865,0.02103822,0.005471107,0.000814721,0.003688748,0.005800663,0.002919119,0.005580877,0.5774531,0.3740152,0.000253526],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.07245594,0.2595215,0.0329873,0.5850025,0.004048153,0.0001929097,0.0005086575,0.0004082857,0.04487476],"genre_scores_gemma":[0.7297823,0.1062073,0.02982283,0.1231851,0.005085914,0.0003369224,0.0002914453,0.0002228519,0.005065183],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005326081,"threshold_uncertainty_score":0.02816731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493160574292039,"score_gpt":0.2516112832705727,"score_spread":0.2366796775276524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}