{"id":"W2075429778","doi":"10.1098/rspb.2014.0566","title":"The path of least resistance: aggressive or moderate treatment?","year":2014,"lang":"en","type":"article","venue":"Proceedings of the Royal Society B Biological Sciences","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council","keywords":"Intensive care medicine; Drug resistance; Dose; Resistance (ecology); Resistance Factors; Medicine; Drug; Path (computing); Risk analysis (engineering); Biology; Computer science; Pharmacology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004186234,0.00009859656,0.0001190895,0.000003074754,0.0004032563,0.00002462805,0.0004707831,0.00009963198,0.00000578933],"category_scores_gemma":[0.0002853598,0.00003730375,0.0001722234,0.0001275902,0.001257794,0.000002215786,0.0001519472,0.00004193553,5.493806e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001058935,"about_ca_system_score_gemma":0.00004837714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008415333,"about_ca_topic_score_gemma":0.000007512059,"domain_scores_codex":[0.9992459,0.00001820628,0.0001675418,0.000225814,0.0001484508,0.0001940551],"domain_scores_gemma":[0.9994513,0.0000364005,0.0002779099,0.0000767341,0.000122748,0.00003492113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001602161,0.0007154853,0.2470897,0.000145813,0.0003989443,1.842439e-7,0.00127408,0.001571523,0.654841,0.04177427,0.0353942,0.01519261],"study_design_scores_gemma":[0.004605134,0.01418559,0.1829725,0.0004099849,0.0002063472,0.00001700109,0.009621406,0.1119178,0.5245587,0.03203324,0.1176434,0.001828846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938347,0.0005318584,0.000143548,0.0005230398,0.00005982481,0.0001291079,0.000009873752,0.000006083556,0.00476192],"genre_scores_gemma":[0.9956494,0.0004967984,0.000964032,0.00009612877,0.00006135341,0.000009955133,0.000001275549,0.00000258903,0.002718467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1302823,"threshold_uncertainty_score":0.4634393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493160574292039,"score_gpt":0.2516112832705727,"score_spread":0.2366796775276524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}