{"id":"W2075435145","doi":"10.1371/journal.ppat.1001314","title":"Global Functional Analyses of Cellular Responses to Pore-Forming Toxins","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Division of Molecular and Cellular Biosciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of California, San Diego; National Institutes of Health; National Science Foundation","keywords":"Interactome; Biology; RNA interference; Caenorhabditis elegans; Cell biology; MAPK/ERK pathway; Gene; Protein kinase A; Signal transduction; Kinase; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009302198,0.0001260071,0.0001503095,0.00004196897,0.0000562665,0.000007752845,0.00009219505,0.0001049226,0.00007597017],"category_scores_gemma":[0.0001000328,0.0001154923,0.000112137,0.0001325275,0.00004172736,0.000003397205,0.00009806741,0.00002697024,0.00001204113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001129766,"about_ca_system_score_gemma":0.00005829471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003650502,"about_ca_topic_score_gemma":0.00002146215,"domain_scores_codex":[0.9991677,0.00004303444,0.0002106661,0.0002567699,0.000115151,0.0002066748],"domain_scores_gemma":[0.9994452,0.000005616011,0.00007484457,0.0002693067,0.000103957,0.0001011054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003099684,0.00008075024,0.006664875,0.000007841545,0.00007176648,0.00001187661,0.00004436994,0.00000282287,0.9920637,0.0000704991,0.0001607397,0.0005107836],"study_design_scores_gemma":[0.0001363202,0.0002736164,0.02733317,0.00001209383,0.00005212808,0.00001177866,0.00006672163,0.000006136086,0.9707267,0.00001505493,0.001223621,0.0001426325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968638,0.0001098329,0.0007398968,0.00002198809,0.0001436343,0.00008953168,0.0001787321,0.00001177804,0.00184081],"genre_scores_gemma":[0.9948478,0.00001104197,0.004535759,0.0001408411,0.0001810145,0.000003178765,0.00009703766,0.00001229685,0.0001710489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02133698,"threshold_uncertainty_score":0.4709641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06319730942963545,"score_gpt":0.2725123973403581,"score_spread":0.2093150879107226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}