{"id":"W2075443265","doi":"10.1139/o10-009","title":"Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase (<i>Escherichia coli</i>)","year":2010,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Light Source (Canada); University of Calgary","funders":"","keywords":"Chemistry; Stereochemistry; Residue (chemistry); lac operon; Ligand (biochemistry); Conformational change; Substrate (aquarium); Crystallography; Enzyme; Transition state analog; Active site; Escherichia coli; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408047,0.0002599452,0.0002599487,0.00005674566,0.0001563042,0.0005199287,0.0003224878,0.0004105469,0.0009152064],"category_scores_gemma":[0.0001684975,0.0001356551,0.0001625364,0.00004633925,0.0002351726,0.0001984497,0.0002901285,0.0002921266,0.0005430663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464682,"about_ca_system_score_gemma":0.0001594734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007019118,"about_ca_topic_score_gemma":0.0003760775,"domain_scores_codex":[0.9999144,0.00001732203,0.000006085629,0.00001996497,0.00002023652,0.00002192744],"domain_scores_gemma":[0.9999263,0.0000117254,0.00001469547,0.000005822122,0.000007994043,0.00003350007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003515187,0.00003590956,0.0003319386,0.00004449696,0.000005764513,0.0001856698,0.0000269122,0.0002590901,0.9937328,0.0002846471,0.00006649842,0.00467479],"study_design_scores_gemma":[0.00006646452,0.000379419,0.002334236,0.0000110529,0.00001191393,0.0004482479,0.00003283424,0.001776189,0.9911142,0.00009009388,0.003724111,0.00001113425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928834,0.001260265,0.002508015,0.0001213308,0.00003314572,0.00001784433,0.00007491946,0.0001724908,0.002928491],"genre_scores_gemma":[0.9970746,0.0002066684,0.001588212,0.00003564134,0.000004732085,0.000004621068,0.00007323051,0.00001782892,0.0009945298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009152064,"threshold_uncertainty_score":0.003061652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006807554508835081,"score_gpt":0.222687579750838,"score_spread":0.2158800252420029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}