{"id":"W2075443265","doi":"10.1139/o10-009","title":"Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase (<i>Escherichia coli</i>)","year":2010,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Light Source (Canada); University of Calgary","funders":"","keywords":"Chemistry; Stereochemistry; Residue (chemistry); lac operon; Ligand (biochemistry); Conformational change; Substrate (aquarium); Crystallography; Enzyme; Transition state analog; Active site; Escherichia coli; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241376,0.00007323833,0.0001175211,0.00001040571,0.00007426299,0.000004931144,0.0001176532,0.0001152397,0.00009092628],"category_scores_gemma":[0.00005604885,0.0000418328,0.00003674407,0.00003579329,0.0002191301,0.00002875349,0.00003202906,0.00006710655,6.407155e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003359665,"about_ca_system_score_gemma":0.00003293115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006578412,"about_ca_topic_score_gemma":0.00001551049,"domain_scores_codex":[0.9995688,0.00001692347,0.0001627202,0.0001040878,0.00005493856,0.00009254731],"domain_scores_gemma":[0.9993489,0.0001401611,0.0002551109,0.0001599803,0.0000774959,0.00001836477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272318,0.0000121167,0.0002451853,0.00009945733,0.000009356,1.862869e-8,0.000126697,5.3504e-7,0.9988151,0.0002509765,0.00006160298,0.0002517927],"study_design_scores_gemma":[0.0002425876,0.00006809384,0.001704338,0.000005469723,0.00002566753,0.000004638125,0.0005364768,0.00001199035,0.9926654,0.000189261,0.004500663,0.0000453792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974131,0.0003005701,0.00003751216,0.00006862336,0.000162155,0.0001196147,0.00009537258,0.000005641854,0.001797412],"genre_scores_gemma":[0.9994599,0.00005068913,0.0001490634,0.00003977336,0.00009774033,0.0000184907,0.00002168795,0.000002870217,0.0001598342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006149596,"threshold_uncertainty_score":0.1705892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006807554508835081,"score_gpt":0.222687579750838,"score_spread":0.2158800252420029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}