{"id":"W2075459950","doi":"10.1038/nsmb.2391","title":"Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation","year":2012,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":362,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"DNA methylation; Biology; Epigenomics; Chromatin; Histone methylation; Methylation; Epigenetics; Genetics; RNA-Directed DNA Methylation; Epigenetics of physical exercise; Cell biology; Histone; DNA; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002752854,0.0002269637,0.0002621221,0.00017377,0.0007311448,0.0006904517,0.0006417946,0.0003934912,0.003599973],"category_scores_gemma":[0.0004571366,0.0003940717,0.0004182888,0.0001473864,0.0004219496,0.0003820407,0.0009028762,0.0007773597,0.001558549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001115123,"about_ca_system_score_gemma":0.0003234359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002280504,"about_ca_topic_score_gemma":0.00344231,"domain_scores_codex":[0.9997488,0.00001662965,0.000008761553,0.00009457173,0.00005279425,0.00007837573],"domain_scores_gemma":[0.9997604,0.00002754852,0.00005203047,0.00004684616,0.00003062408,0.00008241186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002621933,0.00001432851,0.001370335,0.0000342509,0.00002282703,0.00007358201,0.00003005758,0.0001191418,0.9933541,0.0007359391,0.0004448661,0.003538351],"study_design_scores_gemma":[0.00001843593,0.00005086499,0.01305045,0.000004935279,0.00001080815,0.0001894846,0.00003920684,0.0010875,0.9803082,0.0002323723,0.004997709,0.00001000133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788551,0.002733332,0.01187644,0.0005524592,0.0001866524,0.00001482976,0.0003717884,0.0003695445,0.005039753],"genre_scores_gemma":[0.9930782,0.0002632051,0.001897712,0.00007304893,0.00002448121,0.000006311746,0.0003417849,0.00004964071,0.00426558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003599973,"threshold_uncertainty_score":0.01204312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003513971166134164,"score_gpt":0.2714788180870388,"score_spread":0.2679648469209046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}