{"id":"W2075462559","doi":"10.1007/s00125-012-2586-1","title":"Deletion of p47 phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse","year":2012,"lang":"en","type":"article","venue":"Diabetologia","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University Health Network; Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Amgen; Amgen Canada; University of Toronto; Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; NADPH oxidase; P22phox; Diabetic nephropathy; Oxidative stress; Diabetes mellitus; Nephropathy; Insulin; Mesangial cell; Reactive oxygen species; Impaired glucose tolerance; Kidney; Biology; Chemistry; Medicine; Insulin resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977989,0.0008131883,0.0005193237,0.0007874653,0.0003022184,0.000550909,0.0003712982,0.0006078421,0.001916868],"category_scores_gemma":[0.0002232688,0.0004316838,0.000370703,0.0002616529,0.0005725512,0.0006559239,0.0003217916,0.001763994,0.0004828603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000294685,"about_ca_system_score_gemma":0.0003021185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005810512,"about_ca_topic_score_gemma":0.0008986939,"domain_scores_codex":[0.9997095,0.0000446364,0.00003481137,0.000059796,0.00006230585,0.00008888106],"domain_scores_gemma":[0.9992154,0.00004932737,0.0002849674,0.00006012402,0.00004551524,0.0003447455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009203247,0.0002810587,0.000338196,0.00003975069,0.00001120309,0.00008378002,0.00002164673,0.00007598793,0.9965553,0.0002009282,0.00007008426,0.001401773],"study_design_scores_gemma":[0.0001546388,0.001109726,0.01151885,0.00002528618,0.00007535335,0.0003663098,0.000105648,0.002123378,0.9825382,0.0002695721,0.001695103,0.00001799843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948294,0.0005824096,0.002920728,0.0002469822,0.00005535263,0.0000179423,0.0003212999,0.0001808591,0.0008450558],"genre_scores_gemma":[0.9888101,0.001072146,0.003044667,0.0001543031,0.00004118994,0.0000566318,0.0005011284,0.0001335906,0.006186366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916868,"threshold_uncertainty_score":0.006412506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425131826656851,"score_gpt":0.2469886779689107,"score_spread":0.2327373597023422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}