{"id":"W2075465550","doi":"10.1002/cmdc.201400024","title":"Simplified Silvestrol Analogues with Potent Cytotoxic Activity","year":2014,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"In vivo; In vitro; Cytotoxic T cell; Biochemistry; Chemistry; Cytotoxicity; Cancer cell; Membrane permeability; Cell culture; Biology; Stereochemistry; Cancer; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007477425,0.0004403012,0.0002581176,0.0002552139,0.0001107145,0.0002278155,0.0002215072,0.0001898904,0.002395777],"category_scores_gemma":[0.00009723438,0.0001017326,0.0001901827,0.0002739776,0.0001568653,0.0001864125,0.000155069,0.0004756355,0.0004414534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639858,"about_ca_system_score_gemma":0.0001708832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004405771,"about_ca_topic_score_gemma":0.001028117,"domain_scores_codex":[0.9999387,0.000008881004,0.000007129271,0.00001209753,0.00001803897,0.00001517069],"domain_scores_gemma":[0.9999211,0.00001022119,0.00001984146,0.00001058201,0.00001440825,0.00002386723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002687132,0.00008902354,0.0001115125,0.0001096816,0.0000125454,0.0001323937,0.00002792171,0.0009385111,0.9901695,0.0002958373,0.0001500864,0.007694235],"study_design_scores_gemma":[0.0001160368,0.002059154,0.002409837,0.00001618975,0.00004578912,0.0002861744,0.00002252368,0.0007349023,0.9770323,0.0001138474,0.01714291,0.00002046374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816561,0.0043083,0.004046926,0.0001492543,0.00006099444,0.0001539427,0.001418712,0.0001609288,0.008044855],"genre_scores_gemma":[0.9852356,0.00347817,0.004497978,0.0001229294,0.000029407,0.00006048675,0.00190119,0.00003261298,0.00464154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002395777,"threshold_uncertainty_score":0.008014679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038255299944668,"score_gpt":0.2171830217735612,"score_spread":0.2068004687741145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}