{"id":"W2075465550","doi":"10.1002/cmdc.201400024","title":"Simplified Silvestrol Analogues with Potent Cytotoxic Activity","year":2014,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"In vivo; In vitro; Cytotoxic T cell; Biochemistry; Chemistry; Cytotoxicity; Cancer cell; Membrane permeability; Cell culture; Biology; Stereochemistry; Cancer; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247792,0.0002594856,0.0002529271,0.00002304295,0.00007899786,0.00002930282,0.0002799249,0.0002013952,0.00001431537],"category_scores_gemma":[0.0001441858,0.0001931806,0.0001038472,0.00009362876,0.0002479024,0.000006447277,0.0001492869,0.0001789624,0.00001707818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002666703,"about_ca_system_score_gemma":0.00003385117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007014827,"about_ca_topic_score_gemma":0.000007335138,"domain_scores_codex":[0.99875,0.00005370073,0.0001335367,0.0005111966,0.0001583859,0.0003931342],"domain_scores_gemma":[0.9991716,0.00004835884,0.00009025541,0.0004617976,0.00005995625,0.0001680264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002088145,0.0001201096,0.001031197,0.00001592609,0.00004567419,0.000001256926,0.000007015521,0.000008275942,0.9959759,0.00003297078,0.0006157811,0.001937145],"study_design_scores_gemma":[0.0005160661,0.0004939897,0.003677714,0.000009375915,0.00001452151,0.00001718747,0.00001489129,0.00005986618,0.9891586,0.0004838868,0.005253958,0.0002999883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895764,0.00004984108,0.002897973,0.0002561427,0.00003449462,0.0001504517,0.00001084512,0.00005757031,0.006966294],"genre_scores_gemma":[0.9981076,0.00001074003,0.0005939298,0.0004885415,0.000334059,0.00005642402,0.0001006469,0.00002546593,0.0002826129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008531192,"threshold_uncertainty_score":0.7877676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038255299944668,"score_gpt":0.2171830217735612,"score_spread":0.2068004687741145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}