{"id":"W2075532113","doi":"10.1007/s10637-014-0138-x","title":"Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities","year":2014,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Irinotecan; Diarrhea; Medicine; Camptothecin; Toxicity; Pharmacology; Pharmacokinetics; Gastroenterology; Colorectal cancer; Internal medicine; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003642495,0.0001117983,0.000218583,0.00004257712,0.00002306415,0.000004960564,0.0001665096,0.00006699649,0.000003046186],"category_scores_gemma":[0.0002597721,0.00009243275,0.0001030922,0.00009743653,0.0002045635,0.000006778849,0.00006654725,0.00008217306,5.03115e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009877047,"about_ca_system_score_gemma":0.0002854049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001000728,"about_ca_topic_score_gemma":0.00009259331,"domain_scores_codex":[0.998854,0.00008187509,0.0005347059,0.0001820305,0.0002040732,0.0001433456],"domain_scores_gemma":[0.9991359,0.0001446556,0.0002879822,0.0002242291,0.0001339481,0.0000733475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001202998,0.00008812842,0.004434834,0.0000761244,0.00001336479,1.176182e-7,0.0002146933,0.008410358,0.97335,0.0108787,0.0000609382,0.002352458],"study_design_scores_gemma":[0.0009790764,0.0006350923,0.003658837,0.0001253397,0.00001846137,0.000003180603,0.00003783962,0.02559963,0.9568089,0.01190564,0.0001432564,0.00008471626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954336,0.0000811323,0.003790519,0.0003326303,0.00007329896,0.0001842455,0.000009471299,0.000003798679,0.00009126939],"genre_scores_gemma":[0.9950067,0.00001861496,0.004480786,0.0002376223,0.000120378,0.00001238695,0.00001833434,0.00001217385,0.00009304684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01718927,"threshold_uncertainty_score":0.3769298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234114526948035,"score_gpt":0.2835922386419162,"score_spread":0.2601807859471127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}