{"id":"W2075532113","doi":"10.1007/s10637-014-0138-x","title":"Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities","year":2014,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Irinotecan; Diarrhea; Medicine; Camptothecin; Toxicity; Pharmacology; Pharmacokinetics; Gastroenterology; Colorectal cancer; Internal medicine; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545415,0.0008803402,0.0006726259,0.0005699508,0.0002200107,0.0002458605,0.0003252764,0.0006088585,0.001359302],"category_scores_gemma":[0.0001526457,0.000273776,0.0004625154,0.0002138337,0.0003897647,0.0005134781,0.0001711134,0.001504318,0.0003145477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004182306,"about_ca_system_score_gemma":0.000620522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582599,"about_ca_topic_score_gemma":0.002401546,"domain_scores_codex":[0.9997631,0.00003124003,0.0000225462,0.00004348389,0.00006033181,0.00007939032],"domain_scores_gemma":[0.9997676,0.00002323397,0.00007179927,0.00002208914,0.00004658568,0.00006877476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005878497,0.0004530755,0.00006051861,0.00007869612,0.000008484797,0.00005965859,0.00002598934,0.0001638764,0.9966232,0.00006992118,0.00006401465,0.00180485],"study_design_scores_gemma":[0.00005322469,0.005555298,0.0008452694,0.000007505165,0.0000242294,0.00009039374,0.00002462877,0.0005535218,0.9919314,0.00002199016,0.0008857911,0.000006741002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926165,0.001187663,0.003466272,0.0002033774,0.000115395,0.0001450869,0.0003498566,0.0001981288,0.001717829],"genre_scores_gemma":[0.9857783,0.00212141,0.004396568,0.00009808006,0.00003292572,0.0001692285,0.0006525299,0.00003292604,0.006717981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001582599,"threshold_uncertainty_score":0.004547358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234114526948035,"score_gpt":0.2835922386419162,"score_spread":0.2601807859471127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}