{"id":"W2075548587","doi":"10.1182/blood.v97.3.720","title":"Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency","keywords":"Biology; Myeloid leukemia; CD38; Interleukin 3; Progenitor cell; CD34; Leukemia; Cancer research; Population; Myeloid; Molecular biology; Growth factor; ABL; Immunology; Stem cell; Cell biology; T cell; Interleukin 21; Signal transduction; Immune system; Tyrosine kinase; Medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001372668,0.0002133724,0.0003272609,0.0003574327,0.0001882571,0.0003408039,0.0001349109,0.0001506882,0.001832231],"category_scores_gemma":[0.0003194694,0.0001235585,0.0001380945,0.0002622193,0.0001549982,0.0001463079,0.0002336978,0.0003751956,0.0006082325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001389565,"about_ca_system_score_gemma":0.000141401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003300045,"about_ca_topic_score_gemma":0.0003581132,"domain_scores_codex":[0.9998904,0.00002021382,0.00001348325,0.0000212936,0.00002925719,0.00002531388],"domain_scores_gemma":[0.9998103,0.00005558363,0.00002554287,0.00002886596,0.00001498688,0.00006472204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007780503,0.00009742273,0.01663622,0.00005344988,0.00001493899,0.0005807773,0.0002914239,0.0001187336,0.9715739,0.0002043881,0.0002624703,0.009388229],"study_design_scores_gemma":[0.0003741883,0.005270483,0.2815627,0.00006183354,0.000147156,0.01766217,0.0003477598,0.002684965,0.6660384,0.0007160248,0.02509559,0.00003869813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954637,0.001482927,0.00106271,0.00004020828,0.00001074842,0.00004820587,0.0003789627,0.0000717346,0.001440758],"genre_scores_gemma":[0.9959909,0.0004681561,0.0008509518,0.00006265062,0.00002118816,0.00005746957,0.001654956,0.00001720004,0.000876461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001832231,"threshold_uncertainty_score":0.006129384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006904935077660119,"score_gpt":0.2076230744175077,"score_spread":0.2007181393398476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}