{"id":"W2075549508","doi":"10.1073/pnas.041449398","title":"Production of zebrafish germ-line chimeras from embryo cell cultures","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Biology; Zebrafish; Embryonic stem cell; Germ cell; Cell biology; Embryo; Chimera (genetics); Stem cell; Cell culture; Gene targeting; Cellular differentiation; Genetics; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002670627,0.00006225491,0.00008210803,0.00004006426,0.00005128637,0.000005394662,0.0003119259,0.00006390213,0.000006722159],"category_scores_gemma":[0.0001669268,0.00004363442,0.00005242084,0.0002147589,0.0002162106,0.00001120087,0.000069057,0.00005564254,2.488613e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003571162,"about_ca_system_score_gemma":0.00001316348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006911464,"about_ca_topic_score_gemma":1.442416e-7,"domain_scores_codex":[0.9992085,0.0000022596,0.0001849551,0.0001756933,0.0003502581,0.00007834744],"domain_scores_gemma":[0.999632,0.000007357818,0.0001782049,0.000009216516,0.0001563631,0.00001685183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001084882,0.00002790697,0.002298938,0.00001852114,0.000008769762,1.017935e-9,0.00005119893,0.0006928749,0.9956654,0.0001698049,0.000927626,0.000128124],"study_design_scores_gemma":[0.00008343095,0.00003815508,0.04288345,0.00001975692,0.000007990702,0.000002537021,0.00007070258,0.0001315737,0.954682,0.001289237,0.0007428035,0.00004835195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969228,0.0005123019,0.000006944194,0.0006486914,0.00003567177,0.00007706283,0.000008170076,0.000002893341,0.001785462],"genre_scores_gemma":[0.9981254,0.0001452753,0.001127241,0.00005872642,0.0002001255,0.000002637164,8.491833e-7,0.000002925151,0.0003367592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04098338,"threshold_uncertainty_score":0.177936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620100194585015,"score_gpt":0.3099402357895429,"score_spread":0.2937392338436927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}