{"id":"W2075565987","doi":"10.2353/ajpath.2006.050369","title":"Transforming Growth Factor-β2 Suppresses Collagen Cleavage in Cultured Human Osteoarthritic Cartilage, Reduces Expression of Genes Associated with Chondrocyte Hypertrophy and Degradation, and Increases Prostaglandin E2 Production","year":2006,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; Montreal General Hospital; Jewish General Hospital; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research; Canadian Arthritis Network; National Institute on Aging; National Institutes of Health; Shriners Hospitals for Children","keywords":"Chondrocyte; Aggrecan; Cartilage; Type II collagen; Growth factor; Transforming growth factor; Endocrinology; Chemistry; Internal medicine; Prostaglandin E2; Matrix metalloproteinase; Cell biology; Osteoarthritis; Biology; Medicine; Pathology; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075709,0.0006135341,0.0004277478,0.0006420491,0.0002165577,0.0003510564,0.0001968039,0.0002507219,0.001651946],"category_scores_gemma":[0.0002091719,0.0002907604,0.000494528,0.0002872098,0.0004792013,0.0001196593,0.0001585478,0.0007213263,0.0006660821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270415,"about_ca_system_score_gemma":0.0004296319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001726122,"about_ca_topic_score_gemma":0.00193178,"domain_scores_codex":[0.9997469,0.00005793406,0.00002534234,0.00002378541,0.00007059977,0.00007544138],"domain_scores_gemma":[0.9997936,0.00004224165,0.00003178687,0.00003446361,0.00002124969,0.00007664278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00065023,0.0001060845,0.0001879508,0.00002618156,0.000007341096,0.0001005019,0.00001687202,0.00002274206,0.9979717,0.00003354506,0.00005991882,0.0008168734],"study_design_scores_gemma":[0.0001450418,0.001205705,0.005891368,0.000007210748,0.00002143562,0.0004670024,0.00006710694,0.0002668397,0.9901246,0.00004995046,0.001747133,0.000006566488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939802,0.002569868,0.0009184579,0.0001474021,0.00009717187,0.00003643024,0.0003615529,0.00007614033,0.001812781],"genre_scores_gemma":[0.9904125,0.0018486,0.0009955938,0.0001282934,0.00005937707,0.00005094133,0.00143302,0.00003310197,0.005038452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001726122,"threshold_uncertainty_score":0.005526304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008051811775811787,"score_gpt":0.2315714678079367,"score_spread":0.2235196560321249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}