{"id":"W2075565987","doi":"10.2353/ajpath.2006.050369","title":"Transforming Growth Factor-β2 Suppresses Collagen Cleavage in Cultured Human Osteoarthritic Cartilage, Reduces Expression of Genes Associated with Chondrocyte Hypertrophy and Degradation, and Increases Prostaglandin E2 Production","year":2006,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; Montreal General Hospital; Jewish General Hospital; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research; Canadian Arthritis Network; National Institute on Aging; National Institutes of Health; Shriners Hospitals for Children","keywords":"Chondrocyte; Aggrecan; Cartilage; Type II collagen; Growth factor; Transforming growth factor; Endocrinology; Chemistry; Internal medicine; Prostaglandin E2; Matrix metalloproteinase; Cell biology; Osteoarthritis; Biology; Medicine; Pathology; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194043,0.0001519672,0.0005136195,0.0002141615,0.00007665621,0.00001206408,0.00003295439,0.00005529921,0.000003426473],"category_scores_gemma":[0.00009152384,0.0001088067,0.00004180107,0.000188976,0.0002916778,0.0001830369,0.000009551099,0.00008452827,7.179167e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003347662,"about_ca_system_score_gemma":0.00005811056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006574962,"about_ca_topic_score_gemma":0.0002566538,"domain_scores_codex":[0.9989408,0.0001467752,0.0003863117,0.0001844837,0.0001679632,0.0001736657],"domain_scores_gemma":[0.999253,0.00005460333,0.0003839478,0.00006780252,0.0001689194,0.00007170023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005131314,0.0001852114,0.07420189,0.00003083378,0.00001332731,0.0003554712,0.0007099758,9.7007e-7,0.920315,0.00001077479,0.000008806889,0.003654604],"study_design_scores_gemma":[0.003689774,0.007891282,0.04458766,0.0005276568,0.0001604015,0.001767402,0.001545679,2.596848e-7,0.9396242,0.00007719664,0.00001079237,0.0001177085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977563,0.001733899,0.00001496125,0.00008256459,0.0000330952,0.0003181882,0.00001976061,0.0000104186,0.00003078757],"genre_scores_gemma":[0.9985387,0.0002769787,0.001003279,0.00001317015,0.0000632865,0.00001113914,0.00003420267,0.00001684386,0.00004236761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02961423,"threshold_uncertainty_score":0.4437008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008051811775811787,"score_gpt":0.2315714678079367,"score_spread":0.2235196560321249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}