{"id":"W2075590318","doi":"10.1074/mcp.m113.037374","title":"An Unbiased Proteomic Screen Reveals Caspase Cleavage Is Positively and Negatively Regulated by Substrate Phosphorylation","year":2014,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Western University","funders":"National Institute of General Medical Sciences; National Institutes of Health; University of North Carolina at Chapel Hill; National Cancer Institute; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Phosphorylation; Cleavage (geology); Cell biology; Caspase; Proteolysis; Protein phosphorylation; Chemistry; Phosphoserine; Proteomics; Biology; Phosphopeptide; Phosphoproteomics; Apoptosis; Biochemistry; Programmed cell death; Enzyme; Protein kinase A; Serine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002265678,0.000329941,0.0002696493,0.0002722662,0.0001756965,0.0003122997,0.0001592549,0.0002549933,0.0007426176],"category_scores_gemma":[0.0002232303,0.0001377532,0.0002527579,0.0002585672,0.0001557024,0.0001891854,0.0001914488,0.0003346284,0.0003342011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001763011,"about_ca_system_score_gemma":0.0001594445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001594815,"about_ca_topic_score_gemma":0.0004074929,"domain_scores_codex":[0.9997862,0.00002536587,0.00001829338,0.00005504198,0.0000732136,0.0000419666],"domain_scores_gemma":[0.9998471,0.0000355789,0.00004933131,0.00001541793,0.00002285578,0.00002972938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004812345,0.000006139925,0.0002486619,0.00001196617,0.000003885327,0.00002293915,0.000003210855,0.00001264164,0.9992433,0.00001176177,0.000008581392,0.0003787077],"study_design_scores_gemma":[0.000007982432,0.0001598613,0.01500112,0.000003700416,0.00002929366,0.0004294847,0.00001751424,0.0004823984,0.9830756,0.0000337564,0.0007539223,0.000005311795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943537,0.0009670389,0.003183576,0.0000432228,0.00001131164,0.00002446772,0.0005671402,0.00003843875,0.0008111254],"genre_scores_gemma":[0.98973,0.0014015,0.005971576,0.00009411592,0.000009170468,0.000042035,0.001448423,0.00003001391,0.001273158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007426176,"threshold_uncertainty_score":0.002484322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005936731345241912,"score_gpt":0.2115740008819584,"score_spread":0.2056372695367165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}