{"id":"W2075610799","doi":"10.1016/j.clinthera.2008.01.002","title":"Comparative bioavailability of single-dose methylphenidate from a multilayer-release bead formulation and an osmotic system: A two-way crossover study in healthy young adults","year":2008,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Medicine; Bioavailability; Bead; Crossover study; Crossover; Pharmacology; Immediate release; Machine learning","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00192057,0.00116726,0.003431503,0.0005173208,0.0007538222,0.0009757245,0.0007894781,0.001514263,0.002087035],"category_scores_gemma":[0.001973442,0.001165065,0.001288522,0.0004377025,0.001424017,0.001710144,0.0005232278,0.002330563,0.0005141106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00065495,"about_ca_system_score_gemma":0.001109548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002067688,"about_ca_topic_score_gemma":0.002002213,"domain_scores_codex":[0.9987902,0.0004293918,0.0001043481,0.0003235771,0.0001729483,0.0001795656],"domain_scores_gemma":[0.9987679,0.0003520133,0.0002257999,0.0001588208,0.0001522381,0.0003431809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8551872,0.05136001,0.001794933,0.0003884509,0.0004806935,0.00009429729,0.0005248555,0.0002659079,0.07688066,0.00008790044,0.0002908547,0.01264425],"study_design_scores_gemma":[0.0993401,0.8584142,0.01581971,0.00001769492,0.001040133,0.0001038891,0.0002588868,0.001035265,0.02318401,0.0001024814,0.0006011027,0.00008261698],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998848,0.0002155652,0.0002979138,0.00003369914,0.00008079648,0.0002989335,0.0001132089,0.00001607938,0.0000956968],"genre_scores_gemma":[0.9958831,0.0004877314,0.001402223,0.0001083558,0.0001327172,0.0006655137,0.000231395,0.00002332836,0.001065738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003431503,"threshold_uncertainty_score":0.01015705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2718346021186047,"score_gpt":0.4690624820830536,"score_spread":0.1972278799644489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}