{"id":"W2075655804","doi":"10.1016/j.micpath.2005.08.005","title":"Low dose aerosol infection of mice with virulent type A Francisella tularensis induces severe thymus atrophy and CD4+CD8+ thymocyte depletion","year":2005,"lang":"en","type":"article","venue":"Microbial Pathogenesis","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada; National Research Council Canada; Institute for Biological Sciences","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Thymocyte; Francisella tularensis; Virulence; Microbiology; Tularemia; Biology; CD8; Pathogen; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002805122,0.0008879983,0.0006245343,0.0008304086,0.0003522942,0.0004223917,0.0003967461,0.001123519,0.001537976],"category_scores_gemma":[0.0002874759,0.000455559,0.0005152902,0.0002069662,0.0006123789,0.0004986946,0.0003092604,0.002156324,0.0005641494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427278,"about_ca_system_score_gemma":0.0003174779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006996611,"about_ca_topic_score_gemma":0.001357406,"domain_scores_codex":[0.9995255,0.00006135002,0.00002744224,0.00008538044,0.0001255576,0.0001747308],"domain_scores_gemma":[0.9994271,0.0001206077,0.0001315728,0.00007332269,0.00004386808,0.0002036874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003857877,0.0001639244,0.0001964756,0.0000230336,0.000006136184,0.00007385134,0.00002060939,0.00003843126,0.9982059,0.00005005627,0.00005605165,0.0007797564],"study_design_scores_gemma":[0.00008683353,0.002721834,0.008445743,0.00001663657,0.00003716353,0.000438378,0.00008084333,0.0008699123,0.9864542,0.0001308272,0.0007032192,0.00001453469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940298,0.001270752,0.001957777,0.0002003282,0.0001184164,0.00007381725,0.0005008363,0.0002171723,0.001631251],"genre_scores_gemma":[0.9929189,0.000733371,0.001294588,0.0001936027,0.00007298611,0.00009136803,0.0005534763,0.00005942166,0.004082338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537976,"threshold_uncertainty_score":0.005145073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008433144926416768,"score_gpt":0.2200862931797122,"score_spread":0.2116531482532954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}