{"id":"W2075660545","doi":"10.1074/jbc.m112.375378","title":"Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; Hospital for Sick Children; Canadian Institutes of Health Research; Sick Kids Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; U.S. Department of Energy; National Institutes of Health; National Science Foundation","keywords":"Isothermal titration calorimetry; Biochemistry; Biology; Allosteric regulation; Transmembrane domain; Receptor; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007685138,0.0003061981,0.0003055207,0.0001714716,0.0002965409,0.0002964569,0.0004295482,0.0004220081,0.001178373],"category_scores_gemma":[0.0001863858,0.0001840425,0.0002891584,0.0002470948,0.000269255,0.0002183926,0.0002217369,0.0006225253,0.0004066559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001055141,"about_ca_system_score_gemma":0.0003607085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003781333,"about_ca_topic_score_gemma":0.002698534,"domain_scores_codex":[0.9999387,0.000008010795,0.000004018925,0.00001748077,0.00002150648,0.00001028649],"domain_scores_gemma":[0.9999081,0.00001606436,0.00002369661,0.000008576871,0.00001731226,0.00002630155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003306741,0.00006164037,0.001511417,0.0001213581,0.0000149657,0.000754861,0.00006908808,0.0009283063,0.9924445,0.0004642406,0.0004590287,0.002840008],"study_design_scores_gemma":[0.0003031392,0.0007152687,0.1102277,0.00009379492,0.00008912701,0.00387966,0.0004894073,0.03968878,0.8214071,0.0006720365,0.02231432,0.0001197082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918668,0.001899654,0.002915428,0.0002993439,0.00003774573,0.00002629696,0.001271622,0.00008383836,0.001599314],"genre_scores_gemma":[0.990301,0.0008247743,0.002973,0.0001498412,0.00001308354,0.00002171182,0.003923836,0.00002425032,0.001768532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003781333,"threshold_uncertainty_score":0.007655561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771184676105017,"score_gpt":0.2240957610962562,"score_spread":0.206383914335206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}