{"id":"W2075673680","doi":"10.1021/ja9095945","title":"Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Lantibiotics; Lanthionine; Chemistry; Peptide; Stereochemistry; Residue (chemistry); Solid-phase synthesis; Nisin; Peptide synthesis; Combinatorial chemistry; Yield (engineering); Biochemistry; Organic chemistry; Antimicrobial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486457,0.00008251871,0.0002074582,0.000002916201,0.0001247746,0.00001646097,0.0004195764,0.00003594968,0.00001413651],"category_scores_gemma":[0.0001244281,0.00002277954,0.0004814479,0.0003554469,0.000192096,0.00002919244,0.00004967427,0.0002075544,4.423884e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005010822,"about_ca_system_score_gemma":0.00001523729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001360178,"about_ca_topic_score_gemma":8.279703e-7,"domain_scores_codex":[0.9992555,0.00005131676,0.0002524439,0.00007641943,0.0002219718,0.0001422914],"domain_scores_gemma":[0.9991214,0.000144369,0.000556951,0.00006832081,0.00005987143,0.00004912545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002273265,0.0002343537,0.0006932864,0.0000012769,0.00003016109,1.937352e-7,0.00003748503,0.00006020864,0.9944958,0.00002543772,0.0008024928,0.00359658],"study_design_scores_gemma":[0.0001933779,0.0003151381,0.0289902,0.0001337666,0.0001017942,0.00002090648,0.0003330827,0.0008844031,0.9681293,0.0004073919,0.0003815568,0.0001090164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950124,0.00001501205,0.00001096924,0.00470046,0.00004734167,0.00005353111,0.00001620583,0.000003997138,0.0001400911],"genre_scores_gemma":[0.998518,0.00003169603,0.0002540063,0.001037297,0.0001436615,9.637677e-8,4.061877e-7,7.797209e-7,0.0000140193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02829691,"threshold_uncertainty_score":0.09596783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02018691607886113,"score_gpt":0.2855263362023369,"score_spread":0.2653394201234758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}