{"id":"W2075700567","doi":"10.1021/bi048833f","title":"Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II:  P1 Arg Is Required for Maximal Thrombin Inhibition","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"","keywords":"Serpin; Heparin cofactor II; Antithrombin; Scissile bond; Chemistry; Thrombin; Pancreatic elastase; Biochemistry; Serine protease; alpha-2-Macroglobulin; Serine Proteinase Inhibitors; Protease; Enzyme; Biology; Elastase; Heparin; Macroglobulin; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353018,0.0002172393,0.0002639763,0.00001954148,0.00008102263,0.000006402489,0.0001836474,0.0003372314,0.00002261261],"category_scores_gemma":[0.0001142367,0.0001699101,0.0002367361,0.00009071291,0.0002595597,0.00001430093,0.0001550648,0.00008791389,6.309893e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000052016,"about_ca_system_score_gemma":0.0002485462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004134499,"about_ca_topic_score_gemma":0.000004139019,"domain_scores_codex":[0.9987074,0.00002627926,0.0004099152,0.0003797322,0.0002390086,0.000237659],"domain_scores_gemma":[0.9988311,0.000007332661,0.000459518,0.000465484,0.0001676568,0.00006889715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001721766,0.0004756597,0.00007144662,0.0001925041,0.00005982333,7.542515e-7,0.00004871104,0.000001473081,0.9961262,0.00009952737,0.001138284,0.00006382391],"study_design_scores_gemma":[0.002272968,0.000846724,0.00001333201,0.0002098746,0.00004261897,0.00001244532,0.00006973249,0.000004800989,0.9956724,0.0001696183,0.000498914,0.0001865847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966913,0.0002653815,0.0009757894,0.0001169606,0.0001412606,0.0006265879,0.00111114,0.000008064985,0.0000634679],"genre_scores_gemma":[0.9987442,0.00003919302,0.0003473856,0.00005629837,0.0001568772,0.00007872385,0.0003853238,0.00002168053,0.0001702541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052916,"threshold_uncertainty_score":0.6928734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767104263525942,"score_gpt":0.243943976387876,"score_spread":0.2262729337526166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}