{"id":"W2075700567","doi":"10.1021/bi048833f","title":"Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II:  P1 Arg Is Required for Maximal Thrombin Inhibition","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"","keywords":"Serpin; Heparin cofactor II; Antithrombin; Scissile bond; Chemistry; Thrombin; Pancreatic elastase; Biochemistry; Serine protease; alpha-2-Macroglobulin; Serine Proteinase Inhibitors; Protease; Enzyme; Biology; Elastase; Heparin; Macroglobulin; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648014,0.0004493624,0.0003694216,0.00008527605,0.0001059904,0.0003574426,0.0003640776,0.0002729313,0.0009949626],"category_scores_gemma":[0.0002829069,0.0001898917,0.0002723015,0.0001727991,0.0002851776,0.0001812025,0.0001865763,0.0004915379,0.0004879243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898764,"about_ca_system_score_gemma":0.0003146467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009213774,"about_ca_topic_score_gemma":0.0009272096,"domain_scores_codex":[0.9997908,0.0000412199,0.00002696331,0.0000366991,0.00005850355,0.0000457824],"domain_scores_gemma":[0.9997179,0.00005731541,0.0001073961,0.00003160848,0.00001763886,0.00006812056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000158269,0.00002869487,0.0001682413,0.00002053022,0.000007133835,0.00005662415,0.000009032999,0.0001421862,0.998675,0.00005808238,0.00001944628,0.0006567602],"study_design_scores_gemma":[0.00002452653,0.0001918979,0.002677885,0.000004969153,0.00001480047,0.0003088535,0.00001323053,0.001138468,0.9941143,0.00002490327,0.001478332,0.000007847716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971514,0.0005128054,0.001518216,0.00004125703,0.00001573977,0.00002036511,0.0001964936,0.00005234791,0.0004913803],"genre_scores_gemma":[0.997252,0.0001865567,0.001487472,0.00002651843,0.000006828902,0.00001594074,0.0004075665,0.00002936585,0.000587725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009949626,"threshold_uncertainty_score":0.003328443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767104263525942,"score_gpt":0.243943976387876,"score_spread":0.2262729337526166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}