{"id":"W2075713006","doi":"10.1038/tpj.2009.11","title":"A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo","year":2009,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"CYP2A6; Nicotine; Allele; Nonsynonymous substitution; In vivo; Biology; Genetics; Biochemistry; Enzyme; Cytochrome P450; Gene; CYP3A4","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004216033,0.0006861863,0.0007579637,0.0005094432,0.0007874689,0.0001823505,0.001124451,0.0004224362,0.0008188176],"category_scores_gemma":[0.000114853,0.0005642136,0.0002307624,0.0009001123,0.0003162173,0.000679212,0.0001352109,0.003620804,0.00003487819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006720008,"about_ca_system_score_gemma":0.0004340338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005717223,"about_ca_topic_score_gemma":0.0002312854,"domain_scores_codex":[0.9949947,0.001204798,0.001072151,0.0007000492,0.0005388017,0.001489512],"domain_scores_gemma":[0.997624,0.0002730329,0.0007941591,0.0003976663,0.0002517639,0.000659345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003658158,0.00240491,0.004223201,0.000008714589,0.0002757842,0.0004698676,0.002596594,0.01408988,0.9569501,0.0001139147,0.0006833158,0.01452557],"study_design_scores_gemma":[0.03443613,0.0008518304,0.03193104,0.0001427882,0.001008405,0.001403673,0.0003988195,0.1379763,0.7489461,0.00113236,0.03960173,0.002170863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920839,0.00149049,0.000492138,0.002110741,0.001252205,0.0007603244,0.0002376659,0.00007355831,0.001498978],"genre_scores_gemma":[0.9906635,0.002286884,0.0002549811,0.005570695,0.0008906304,0.00003066106,0.00002220862,0.00007431287,0.0002061275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.208004,"threshold_uncertainty_score":0.9996809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1142663165519642,"score_gpt":0.4040458957193671,"score_spread":0.2897795791674028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}