{"id":"W2075720135","doi":"10.1016/j.ymthe.2006.08.461","title":"399. Solid Nanobeads Prevents Polycations from Entering the Nuclei and Enhanced Transfection Efficiency","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Transfection; Molecular biology; DNA; Gene delivery; Reporter gene; Nuclease; Biology; Ethyleneimine; Luciferase; Exogenous DNA; Genetic enhancement; Gene; Chemistry; Gene expression; Biochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005796938,0.000123018,0.0000804098,0.00002250925,0.0001187626,0.00003899639,0.0001434192,0.00007459367,0.00002047361],"category_scores_gemma":[0.000003694638,0.00009683221,0.00007610572,0.00005517115,0.00005307017,0.000004404173,0.00002294943,0.00005328254,0.000007752514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006578386,"about_ca_system_score_gemma":0.00001527622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002047183,"about_ca_topic_score_gemma":0.00003742533,"domain_scores_codex":[0.9993069,0.00005613502,0.0001356289,0.0002618775,0.00008576069,0.000153702],"domain_scores_gemma":[0.9996536,0.000005273181,0.00003582611,0.0002533157,0.00002759661,0.00002435734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004369428,0.00005742588,0.000172242,0.00000124622,0.00003497651,9.686355e-7,0.0000831237,0.00008281941,0.9927577,0.00002231198,0.00005804531,0.006685399],"study_design_scores_gemma":[0.0004180288,0.0001929264,0.00348969,0.000009819823,0.000009399449,0.000003559409,0.00003036623,0.00007164304,0.9931728,0.0002300384,0.002252581,0.0001191825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9557158,0.002256269,0.04116812,0.0001334107,0.0001155872,0.0001775064,0.0000109682,0.00001303362,0.0004093265],"genre_scores_gemma":[0.9985542,0.0005582545,0.00009186262,0.0003276718,0.0001041528,0.00003367271,0.00006808176,0.00001729955,0.0002448639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04283836,"threshold_uncertainty_score":0.3948703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005161756414955313,"score_gpt":0.2304701602457175,"score_spread":0.2253084038307622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}