{"id":"W2075741568","doi":"10.1074/jbc.m107182200","title":"Glycogen Synthase Kinase-3β Is Complexed with Tau Protein in Brain Microtubules","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"GSK-3; Microtubule; Hyperphosphorylation; Neurodegeneration; Tau protein; Microtubule-associated protein; Chemistry; Phosphorylation; Glycogen synthase; Tubulin; Cell biology; GSK3B; Biology; Alzheimer's disease; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001164409,0.0004112151,0.0002445728,0.0004899785,0.0004675178,0.0003768775,0.0001789068,0.0002140014,0.002018712],"category_scores_gemma":[0.0001672494,0.0003330225,0.0002635359,0.0003451155,0.0002274776,0.0002463639,0.0003066322,0.0003656235,0.0008968961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007080893,"about_ca_system_score_gemma":0.0004618444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129393,"about_ca_topic_score_gemma":0.003521765,"domain_scores_codex":[0.9998653,0.00001344687,0.00001115801,0.00004578497,0.00004159829,0.0000226103],"domain_scores_gemma":[0.9999363,0.00000317696,0.00002735478,0.000003781504,0.0000096901,0.00001977983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000195978,0.00002690411,0.00279527,0.0001146423,0.00003518367,0.0003291431,0.00005451495,0.00004989171,0.9928997,0.0002543367,0.0003296649,0.002914798],"study_design_scores_gemma":[0.00009431151,0.0002381152,0.1856083,0.00008720542,0.0001166973,0.003092577,0.0001997203,0.003121239,0.7870095,0.001410507,0.01898327,0.00003863334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758955,0.01322228,0.005037124,0.0005027471,0.0001474542,0.0000614952,0.0006036075,0.0001848656,0.004344988],"genre_scores_gemma":[0.9847367,0.004233439,0.002672546,0.0001268809,0.00003567092,0.0000603423,0.001458979,0.00002730632,0.00664799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002129393,"threshold_uncertainty_score":0.006753266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02359078333458521,"score_gpt":0.2345325158189653,"score_spread":0.21094173248438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}